Weighted next reaction method and parameter selection for efficient simulation of rare events in biochemical reaction systems 英文论文文献.docVIP

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Weighted next reaction method and parameter selection for efficient simulation of rare events in biochemical reaction systems 英文论文文献.doc

Weighted next reaction method and parameter selection for efficient simulation of rare events in biochemical reaction systems 英文论文文献

XuandCaiEURASIPJournalonBioinformaticsandSystemsBiology2011,2011:4 /content/2011/1/4/ RESEARCH OpenAccess Weightednextreactionmethodandparameter selectionforefficientsimulationofrareeventsin biochemicalreactionsystems ZhouyiXuandXiaodongCai* Abstract Theweightedstochasticsimulationalgorithm(wSSA)recentlydevelopedbyKuwaharaandMuraandtherefined wSSAproposedbyGillespieetal.basedontheimportancesamplingtechniqueopenthedoorforefficient estimationoftheprobabilityofrareeventsinbiochemicalreactionsystems.Inthispaper,wefirstapplythe importancesamplingtechniquetothenextreactionmethod(NRM)ofthestochasti

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