Weighted next reaction method and parameter selection for efficient simulation of rare events in biochemical reaction systems 英文论文文献.docVIP
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Weighted next reaction method and parameter selection for efficient simulation of rare events in biochemical reaction systems 英文论文文献
XuandCaiEURASIPJournalonBioinformaticsandSystemsBiology2011,2011:4
/content/2011/1/4/
RESEARCH
OpenAccess
Weightednextreactionmethodandparameter
selectionforefficientsimulationofrareeventsin
biochemicalreactionsystems
ZhouyiXuandXiaodongCai*
Abstract
Theweightedstochasticsimulationalgorithm(wSSA)recentlydevelopedbyKuwaharaandMuraandtherefined
wSSAproposedbyGillespieetal.basedontheimportancesamplingtechniqueopenthedoorforefficient
estimationoftheprobabilityofrareeventsinbiochemicalreactionsystems.Inthispaper,wefirstapplythe
importancesamplingtechniquetothenextreactionmethod(NRM)ofthestochasti
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