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Weighted selective collapsing strategy for detecting rare and common variants in genetic association study 英文论文文献.docVIP

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Weighted selective collapsing strategy for detecting rare and common variants in genetic association study 英文论文文献.doc

    Weighted selective collapsing strategy for detecting rare and common variants in genetic association study 英文论文文献

    Daietal.BMCGenetics2012,13:7 /1471-2156/13/7 METHODOLOGY ARTICLE OpenAccess Weightedselectivecollapsingstrategyfor detectingrareandcommonvariantsingenetic associationstudy YilinDai*,RenfangJiangandJianpingDong Abstract Background:Genome-wideassociationstudies(GWAS)havebeenusedsuccessfullyindetectingassociations betweencommongeneticvariantsandcomplexdiseases.However,commonSNPsdetectedbycurrentGWAS onlyexplainasmallproportionofheritablevariability.Withthedevelopmentofnext-generationsequencing technologies,researchersfindmoreandmoreevidencetosupporttheroleplayedbyrarevariantsinheritable variab

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