原创力文档Wavelet-based identification of DNA focal genomic aberrations from single nucleotide polymorphism arrays 英文论文文献.docVIP
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Wavelet-based identification of DNA focal genomic aberrations from single nucleotide polymorphism arrays 英文论文文献
HurandLeeBMCBioinformatics2011,12:146
/1471-2105/12/146
RESEARCH ARTICLE
OpenAccess
Wavelet-basedidentificationofDNAfocal
genomicaberrationsfromsinglenucleotide
polymorphismarrays
YoungmiHur1andHyunjuLee2*
Abstract
Background:Copynumberaberrations(CNAs)areanimportantmolecularsignatureincancerinitiation,
development,andprogression.However,theseaberrationsspanawiderangeofchromosomes,makingithardto
distinguishcancerrelatedgenesfromothergenesthatarenotcloselyrelatedtocancerbutarelocatedinbroadly
aberrantregions.Withthecurrentavailabilityofhigh-resolutiondatasetssuchassinglenucleotidepolymorphis
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