Ⅱ型毛玻璃样肝细胞在乙肝相关型肝细胞癌癌旁组织中的表达及意义.pdfVIP

Abstract ABSTRACT Background ： Primairy hepatocellar carcinoma(HCC) is a common cancer with high degree of malignance in the digestive system, and the treatment effect is not ideal. The development of HCC is concealed, there are non-specific clinical manifestation in the early stage and it becomes advanced quickly with poor prognosis. So far,the clinician generally considered that the hepatitis B virus(HBV) infection is associated with HCC. In China, in particular, chronic hepatitis B virus is the most etiologic reason in many pathogenic factors of HCC. the pathogenesis of HBV-related HCC previously proposed including the inflammation and regeneration, functional gene product of HBV, HBV genome insertion mutation, etc. In recent years, some foreign scholars have found that the type Ⅱground glass hepatocytes (GGHs) is highly expressed in the adjacent to carcinoma and represent the precancerous lesions of the HBV-related HCC. Type Ⅱ GGHs contain pre-S2 mutants, endoplasmic reticulum(ER) stress-dependent and-independent pathways induced by pre-S2 mutants lead to oxidative DNA damage, genomic instability, cell cycle progression and cell proliferation, these mentioned result in type ⅡGGHs growth advantage, and ultimately the formation of HCC. In addition, type ⅡGGHs contain X protein(HBx), which plays an important role in the duplication of HBV and HBV-induced liver disease(including hepatitis, cirrhosis and HCC). Experimental studies have found that transgenic mice harboring either HBx or pre-S2 mutant plasmids developed HCCs, ultimately. In addition, 5%-10% 0f type ⅡGGHs co-express pre-S2 mutant and HBx, and exhibit