Wnt signaling in development and disease 英文论文文献.docVIP

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Wnt signaling in development and disease 英文论文文献.doc

Wnt signaling in development and disease 英文论文文献

YangCellBioscience2012,2:14 /2/1/14 Cell Bioscience REVIEW OpenAccess Wntsignalingindevelopmentanddisease YingziYang* Abstract Cellsignalingmediatedbymorphogensisessentialtocoordinategrowthandpatterning,twokeyprocessesthat governtheformationofacomplexmulti-cellularorganism.Duringgrowthandpatterning,cellsarespecifiedby bothquantitativeanddirectionalinformation.Whilequantitativeinformationregulatescellproliferationand differentiation,directionalinformationisconveyedintheformofcellpolaritiesinstructedbylocalandglobalcues. MajormorphogenslikeWntsplaycriticalrolesinembryonicdevelopmentandtheyare

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