巨噬细胞参与调控肿瘤化疗耐药性的研究进展.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 16, 51 ( 10): 1513 1519 ·1513 · 噬细胞参与调控肿瘤化疗耐药性的研究进展 陈卉卉, 梁桂开, 姚张婷, 张洁琼, 羲, 丁 玲* (浙江大学药学院, 浙江 杭州 3 10058) 摘要: 肿瘤相关巨噬细胞 (tumor-associated macrophages, TAMs) 是肿瘤微环境中极其重要的一类炎症细胞, 能够分泌多种趋化因子和细胞因子, 在肿瘤的发生、发展和转移中发挥重要的作用。近年来, 越来越多的研究发 现巨噬细胞会参与调控肿瘤化疗耐 , 其分泌产生的化学物质会影响化疗 物的疗效。此外, 一些化疗 物会影 响巨噬细胞在肿瘤组织中的募集或生物学活性, 进而影响其自身的抗肿瘤效应。本文就巨噬细胞在肿瘤化疗耐 药中发挥的作用及其调控机制进行综述, 并据此对靶向TAMs 的临床治疗策略进行简单的概述。 关键词: 恶性肿瘤; 巨噬细胞; 化疗耐 中图分类号: R963 文献标识码: A 文章编号: 0513-4870 (20 16) 10- 1513-07 Advances in study of macrophages in chemotherapy resistance of cancer * CHEN Hui-hui, LIANG Gui-kai, YAO Zhang-ting, ZHANG Jie-qiong, CHEN Xi, DING Ling (College of Pharmaceutical Sciences, Zheji ang University, Hangzhou 310058, China ) Abstract : As extremely important inflammatory cells in the tumor microenvironment, tumor-associated macrophages (TAMs) can secrete a variety of chemokines and cytokines, which play an important role in the occurrence of tumor growth and metastasis. Recent years, increasing studies have shown that macrophages are associated with tumor chemotherapy sensitivity. The chemical substances produced by macrophages affect the efficacy of chemotherapeutic agents. In addition, some chemotherapeutic agents have an effect on the recruitment and bioactivity of macrophages