小叶黄杨叶降血脂作用研究.docVIP

　　小叶黄杨叶降血脂作用研究 作者：李勇文，杨成芳，张惠勤，李丽 【摘要】 　　目的研究小叶黄杨叶不同提取物的降血脂作用。方法选用系统溶媒(石油醚、醋酸乙酯、氯仿、正丁醇、水)的方法对小叶黄杨叶进行提取，观察各提取物对腹腔注射75%蛋黄乳液致高血脂症模型小鼠血清总胆固醇及甘油三酯的影响。结果小叶黄杨叶醋酸乙酯提取物的高、低两个剂量组均有显著的降低血清总胆固醇和甘油三酯的作用，小叶黄杨叶的水提取物和石油醚提取物均有显著的降低血清中总胆固醇的作用，小叶黄杨叶氯仿提取物及正丁醇提取物均无降血脂的作用。结论小叶黄杨叶醋酸乙酯提取物对高血脂症小鼠有降血脂作用。 【关键词】 小叶黄杨叶 提取物 降血脂 　　Abstract：ObjectiveTo study the antihyperlipidemia effects of diferent Buxus microphylla leaf extracts．MethodsDifferent extracts Buxus microphylla leaf by systematic solvents (petroleum benzin，ethyl acetate，chloroform，n-butyl alcohol and ia effects of different extracts levels of total cholesterol and triglyceride in hyperlipidemia models，ulsion. ResultsThe Buxus microphylla leaf ethyl acetate extract (high dose and lo total cholesterol and triglyceride. Moreover，the effect of high-dose ethyl acetate extract total cholesterol, and the chloroform extract and n-butyl alcohol extract had no remarkable effect on blood lipid. ConclusionBuxus microphylla leaf ethyl -acetate extract is the active part of Buxus microphylla leaf in reducing blood lipid. 　　Key icrophylla leaf Extracts Antihyperlipidemia effect 　　Buxus Microphylla leaf is the dry leaf from Buxus microphylla. (Family Genus). According to the “pendium of Materia Medica”, Buxus microphylla can promote floinate pathogenic eridian.Cyclovirobuxine D is one kind of alkaloid extracted from the rhizome of Buxus Microphylla and other plants belonged to the same Genus［1］. In recent years, clinically and experimentally Cyclovirobuxine D plays a good role in anti-arrythmia, anti-myocardial Ischemia and strengthening heart, and it has protective function to the acute brain ischemia because it can pass through the blood brain barrier, suppress the formation of thrombus, improve microcycle［2-3］, hoacological research reports on the Buxus Microphylla leaf has been seen in the literature.In this experiment solvent extract from buxus microphylla leaf on the serum total cholesterol and triglyceride in hyperlipidemia model