Bio-分子细胞生物学十年——挑战与成就Adecadeofmolecularcellbiologyachievementsandchallenges.pdfVIP

PERSPECTIVES a reaction–diffusion mechanism. I attribute 1 0 - Y E A R A N N I V E R S A RY S E R I E S — V I E W P O I N T this concept to Eric Karsenti, who mooted the idea in the mid 1980s for signals dif- A decade of molecular cell biology: fusing away from DNA in eggs. However, it wasn’t proven until the development of achievements and challenges fluorescence resonance energy transfer (FRET)-based activity biosensors in the past decade2,3. In general, fluorescence sensors Asifa Akhtar, Elaine Fuchs, Tim Mitchison, Reuben J. Shaw, Daniel St Johnston, of biochemical activity are a very important Andreas Strasser, Susan Taylor, Claire Walczak and Marino Zerial development. Abstract | Nature Reviews Molecular Cell Biology celebrated its 10‑year anniversary Reuben J. Shaw. One area close to our own during this past year with a series of specially commissioned articles. work is the unexpected re-emergence of To compl