CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells英文文献资料.docVIP

下载本文档

6
0
约3.23万字
约 10页
2017-05-09 发布于上海
举报
版权申诉

CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells英文文献资料.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2010,ArticleID410893,9pages doi:10.1155/2010/410893 ResearchArticle CpGOligodeoxynucleotidesEnhancetheEf?cacyofAdoptiveCell TransferUsingTumorIn?ltratingLymphocytesbyModifyingthe Th1PolarizationandLocalIn?ltrationofTh17Cells LinXu, 1 ChunhongWang, 2 ZhenkeWen, 3 4 5 YaZhou, ZhongminLiu, YongjieLiang, 6 ZengguangXu, 7 andTaoRen 6 1 2 3 DepartmentofImmunology,ZunyiMedicalCollege,Guizhou563003,China DepartmentofChestMedicine,QingdaoChestHospital,Shandong266043,China InstituteforImmunobiologyandDepartmentofImmunology,ShanghaiMedicalCollege,FudanUniversity,Shanghai200032, China 4 5 6 DepartmentofMedicalPhysics,ZunyiMedicalCollege,Guizhou563003,China DepartmentofCardiothoracicSurgery,EastHospital,TongjiUnversitySchoolofMedicine,Shanghai200120,China DepartmentofRespiratoryMedicine,EastHospital,TongjiUnversitySchoolofMedicine,150JimoRoad,PudongNewArea, Shanghai200120,China 7 DepartmentofScienti?cResearch,EastHospital,TongjiUnversitySchoolofMedicine,Shanghai200120,China CorrespondenceshouldbeaddressedtoTaoRen,rentaosh@126.com Received29June2010;Revised13September2010;Accepted26September2010 AcademicEditor:ChaimPutterman Copyright?2010LinXuetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,which permitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Adoptivecelltransferimmunotherapyusingtumorin?ltratinglymphocytes(TILs)wasanimportanttherapeuticstrategyagainst tumors.Butthee?cacyremainslimitedanddevelopmentofnewstrategiesisurgent.RecentevidencesuggestedthatCpG-ODNs mightbeapotentcandidatefortumorimmunotherapy.Herewe?rstlyreportedthatCpG-ODNscouldsigni?cantlyenhancethe antitumore?cacyofadoptivelytransferredTILsinvivoaccompaniedbyenhancedactivitycapacityandproliferationofCD8 TcellsandCD8 Tcells,aswellasaTh1polarizationimmuneresponse.Mostimportantly,wefoundthatCpG-ODNscould + + signi?cantlyelevatethein?ltrationofT