HongYu,M.D,PH.D.PDFVIP

Hong Yu, M.D，PH.D E-mail Address: yu.hong@whu.edu.cn Office Address: 185# DongHu Road, Wuhan, Hubei, 430071 Tel ：027O)；M) Position(s): Professor and Director of Dept. Affiliation(s): Department of Biochemistry and Molecular Biology Research interests / Specialties: Lipoprotein modification and\or anti-oxidative enzymes in atherosclerosis Education and Training M.D., 1987-1992 Hubei Medical University, Wuhan, China Ph.D., 1994-1999 Wuhan University School of Medicine, Wuhan, China Post-doctoral training 1, 2001-2002 Faculty of Sciences, Nancy 1 University, France Post-doctoral training 2, 2003-2005 Dept. of Cardiology, Vanderbilt University Medical Center, USA Research Description My research is to investigate the molecular mechanisms, the prevention and therapy of atherosclerosis. The original focus of my lab was the relationship of lipoproteins and atherosclerosis, including the action of LDL, Lp(a) and HDL in the development of atherosclerosis. In recent study, using lipoproteomics methods and gene knockout mouse model, we found dysfunctional HDL was formed and played a important role in atherogenesis by alteration of protein composition in HDL particles during the process of inflammation and oxidative stress. We explored a detection assay of serum paraoxonase 1 activity, possible application as a biomarker of cardiovascular diseases. We also want to screen out the effective drugs or bioactive peptides for the the prevention and therapy of atherosclerosis. Methionine sulfoxide reductase A (MsrA), a specific enzyme that converts methionine-S-sulfoxide to methionine, plays an important role in the regulation of protein function and the maintenance of redox homeostasis. We also investigate the impact of MsrA overexpression in specific tissues on lipid metabolism and atherosclerosis in apoE or SRBI deficient mice,