2015 ETG 4000抑郁症(额叶与不符相关) 3.7.pdfVIP

Journal of Affective Disorders 174 (2015) 165 –172 Contents lists available at ScienceDirect Journal of Affective Disorders journal homepage: /locate/jad Research report Prefrontal cortex activation is associated with a discrepancy between self- and observer-rated depression severities of major depressive disorder: A multichannel near-infrared spectroscopy study Hiroyuki Akashi, Noa Tsujii n, Wakako Mikawa, Toru Adachi, Eiji Kirime, Osamu Shirakawa Department of Neuropsychiatry, Kinki University Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama, Osaka 589-8511, Japan a r t i c l e i n f o a b s t r a c t Article history: Background: Studies on major depressive disorder (MDD) show that the degree of correlation between Received 7 September 2014 the Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HAMD) varies widely. We Accepted 13 November 2014 aimed to determine whether this discrepancy reflects specific functional abnormalities in the fronto- Available online 24 November 2014 temporal cortex. Keywords: Methods: Mildly depressed or euthymic patients with MDD (n ¼ 52), including 21 patients with MDD Major depressive disorder with the discrepancy, i.e., those with low HAMD17 scores ( r13) but high BDI-II scores ( 428), and 31 Hamilton Depression Rating Scale patients without the discrepancy, i.e., those with low HAMD17 scores and low BDI-II scores ( r28), Beck Depression Inventory participated in t