预混门冬胰岛素30和预混人胰岛素30R治疗2型糖尿病的临床比较_潘天荣.pdfVIP

2007 1 27 1 Cli icalM edici e, Ja . 2007, Vol. 27, No. 1 # 1# # # 30 30R 2 潘天荣 孙莉 邓大同 王长江 (安徽医科大学第一附属医院内分泌科, 合肥 230022) = 2 30( 30) 30R( 30R) 2 68 2, 1B1 30 30R , 30 30R, 12 12 H bA 1c ¹ H bA 1c, 30 30R 2 º 30 2 h 30R (P 0. 01) , » 30 30R, ( P 0. 05) , 30 2, 30 30R , = ; ; ; 2 Com parison of the efficacy and safety b etw een prem ix ed in su lin aspar t and hum an insu lin p rem ix u sed in a tw ice- daily inj ection in th e patients w ith type 2 d iabe tes PAN Tianrong, SUN L ,i DEN G D atong, WAN G Changj iang. D ep artm ent of Endo r inology, the F irstAff iliated H osp ital of A nhu iM ed i al University, H ef ei 230022, A nhu i = A bstract O bj ective To com pare the efficacy a d safety of prem ixed i su li aspartw ith huma i su li prem ix used i a tw ice- daily i jectio i the patie tsw ith type 2 diabetes. M ethod s Sixty- eight cases of i adequate glycem ia co trol by su lfo ylurea a d/ or other oral age tsw ere ra dom ly d ivided i to wt o groups( 1B1) usi g wt ice- daily i su li to a 12- w eek com pariso of BIAsp 30 a d BH I 30. E fficacy was assessed by a alysis of varia ce of 12- week data, adjusted for baseli e leve.l Resu lts BIAsp 30 w as as effective as BH I 30 based o the prmi ary efficacy measure, HbA 1c. Sig ifica t mi provem e tswere observed after breakfast, before lu ch, after di er a d at bedtmi e ( P 0. 01). The umber of major hypoglycaem ic episodesw ith BIAsp 30 w as zero. H owever, the overall risk of both m i or a d major hypoglycaem ia did ot differ sig ifica tly betwee treatme ts. Conc lusion Post- pra dial