Regulation of nuclear factor-κB in intestinal epithelial cells in a cell model of inflammation 外文参考文献.docVIP

ResearchCommunication MediatorsofInflammation,12(5),277á / 283(October2003) BACKGROUND : Interleukin-1 (IL-1), an inflammatory Regulationofnuclearfactor-kBin cytokine whose levels are elevated in inflamed mu- cosa, causes part of its effect on intestinal epithelial intestinalepithelialcellsinacell cells(IEC)throughinducingceramideproduction. Aim:Tostudytheroleofnuclearfactor-kB(NF-kB),a modelofin?ammation pro-inflammatory and anti-apoptotic factor, in IL-1- treatedIEC. Methods: NF-kB activity and levels of apoptotic proteins were assessed by electrophoretic mobility shiftassayandRNA-protec