14-3-3 Mediates Histone Cross-Talk during Transcription Elongation in Drosophila 英文参考文献.docVIP

下载本文档

10
0
约5.58万字
约 12页
2017-05-11 发布于上海
举报
版权申诉

14-3-3 Mediates Histone Cross-Talk during Transcription Elongation in Drosophila 英文参考文献.doc

1、本文档共12页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

14-3-3 Mediates Histone Cross-Talk during Transcription Elongation in Drosophila 英文参考文献

14-3-3MediatesHistoneCross-TalkduringTranscription ElongationinDrosophila CalineS.Karam1,2¤a,WendyA.Kellner1,NaomiTakenaka1,AlexaW.Clemmons1¤b,VictorG.Corces1* 1DepartmentofBiology,EmoryUniversity,Atlanta,Georgia,UnitedStatesofAmerica,2DepartmentofBiology,JohnsHopkinsUniversity,Baltimore,Maryland,United StatesofAmerica Abstract Post-translationalmodificationsofhistoneproteinsmodulatethebindingoftranscriptionregulatorstochromatin.Studies inDrosophilahaveshownthatthephosphorylationofhistoneH3atSer10(H3S10ph)byJIL-1isrequiredspecificallyduring earlytranscriptionelongation.14-3-3proteinsbindH3onlywhenphosphorylated,providingmechanisticinsightsintothe role of H3S10ph in transcription. Findings presented here show that 14-3-3 functions downstream of H3S10ph during transcriptionelongation.14-3-3proteinslocalizetoactivegenesinaJIL-1–dependentmanner.Intheabsenceof14-3-3, levelsofactivelyelongatingRNApolymeraseIIareseverelydiminished.14-3-3proteinsinteractwithElongatorprotein3 (Elp3),anacetyltransferasethatfunctionsduringtranscriptionelongation.JIL-1and14-3-3arerequiredforElp3bindingto chromatin,andintheabsenceofeitherprotein,levelsofH3K9acetylationaresignificantlyreduced.Theseresultssuggest that14-3-3proteinsmediatecross-talkbetweenhistonephosphorylationandacetylationatacriticalstepintranscription elongation. Citation: Karam CS, Kellner WA, Takenaka N, Clemmons AW, Corces VG (2010) 14-3-3 Mediates Histone Cross-Talk during Transcription Elongation in Drosophila.PLoSGenet6(6):e1000975.doi:10.1371/journal.pgen.1000975 Editor:AsifaAkhtar,Max-Planck-InstituteofImmunobiology,Germany ReceivedNovember27,2009;AcceptedMay4,2010;PublishedJune3,2010 Copyright: ? 2010 Karam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyNationalScienceFoundationAwardMCB-0618972.Thefunderhadnoro