1,2-Octanediol, a Novel Surfactant, for Treating Head Louse Infestation Identification of Activity, Formulation, and Randomised, Controlled Trials 英文参考文献.docVIP

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1,2-Octanediol, a Novel Surfactant, for Treating Head Louse Infestation Identification of Activity, Formulation, and Randomised, Controlled Trials 英文参考文献.doc

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1,2-Octanediol, a Novel Surfactant, for Treating Head Louse Infestation Identification of Activity, Formulation, and Randomised, Controlled Trials 英文参考文献

1,2-Octanediol,aNovelSurfactant,forTreatingHead LouseInfestation:IdentificationofActivity,Formulation, andRandomised,ControlledTrials IanF.Burgess1*,PeterN.Lee2,KatrinaKay1,3,RuthJones1,4,ElizabethR.Brunton1 1MedicalEntomologyCentre,InsectResearchDevelopmentLimited,Cambridge,UnitedKingdom,2PNLeeStatisticsandComputingLtd,Sutton,UnitedKingdom, 3Infectioncontrol,NHSLeeds,Leeds,UnitedKingdom,4SouthWestWalesRegionalOffice,CareandSocialServicesInspectorateWales,NationalAssemblyofWales, Wales,UnitedKingdom Abstract Background:Interestindevelopingphysicallyactivepediculicideshasidentifiednewactivesubstances.Theobjectivewas toevaluateanewtreatmentforclinicalefficacy. Methods and Findings: We describe the selection of 1,2-octanediol as a potential pediculicide. Clinical studies were community based. The main outcome measure was no live lice, after two treatments, with follow up visits over 14 days.Study1wasaproofofconceptwith18/20(90%)participantscured.Study2wasamulticentre,parallel,randomised, observer-blind study (520 participants) that compared 0.5% malathion liquid with 1,2-octanediol lotion (20% alcohol) applied2–2.5hoursor8hours/overnight.1,2-octanediollotionwassignificantly(p,0.0005)moreeffectivewithsuccessfor 124/175(70.9%)RR=1.50(97.5%CI,1.22to1.85)for2–2.5hours,and153/174(87.9%)RR=1.86(97.5%CI,1.54to2.26)for 8hours/overnightcomparedwith81/171(47.4%)formalathion.Study3,atwocentre,parallel,randomised,observer-blind study(121participants),compared1,2-octanediollotion,2–2.5hourswith1,2-octanediolalcoholfreemousseappliedfor2– 2.5hours or 8hours/overnight. The mousse applied for 8hours/overnight cured 31/40 (77.5%), compared with 24/40 (60.0%) for lotion (RR=1.29, 95% CI, 0.95 to 1.75; NNT=5.7) but mousse applied for 2–2.5hours 17/41 (41.5%) was less effective than lotion (RR=0.69, 95% CI, 0.44 to 1.08).Adverse events were more common using 1,2-octanediol lotion at both 2–2.5hours (12.0%, p=0.001) and 8hours/overnight (14.9%, p,0.0005), compared with 0.5% malathion (2.3