A Detailed History of Intron-rich Eukaryotic Ancestors Inferred from a Global Survey of 100 Complete Genomes 英文参考文献.docVIP

下载本文档

1
0
约4.39万字
约 9页
2017-05-11 发布于上海
举报
版权申诉

A Detailed History of Intron-rich Eukaryotic Ancestors Inferred from a Global Survey of 100 Complete Genomes 英文参考文献.doc

1、本文档共9页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

A Detailed History of Intron-rich Eukaryotic Ancestors Inferred from a Global Survey of 100 Complete Genomes 英文参考文献

ADetailedHistoryofIntron-richEukaryoticAncestors InferredfromaGlobalSurveyof100CompleteGenomes MiklosCsuros1*,IgorB.Rogozin2,EugeneV.Koonin2* 1Department of Computer Science and Operations Research, Universite′ de Montre′al, Montre′al, Que′bec, Canada, 2National Center for Biotechnology Information, NationalLibraryofMedicine,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica Abstract Protein-coding genes in eukaryotes are interrupted by introns, but intron densities widely differ between eukaryotic lineages.Vertebrates,someinvertebratesandgreenplantshaveintron-richgenes,with6–7intronsperkilobaseofcoding sequence,whereasmostoftheothereukaryoteshaveintron-poorgenes.Wereconstructedthehistoryofintrongainand lossusingaprobabilisticMarkovmodel(MarkovChainMonteCarlo,MCMC)on245orthologousgenesfrom99genomes representingthethreeofthefivesupergroupsofeukaryotesforwhichmultiplegenomesequencesareavailable.Intron-rich ancestorsareconfidentlyreconstructedforeachmajorgroup,with53to74%ofthehumanintrondensityinferredwith 95%confidencefortheLastEukaryoticCommonAncestor(LECA).TheresultsoftheMCMCreconstructionarecompared withthereconstructionsobtainedusingMaximumLikelihood(ML)andDolloparsimonymethods.Anexcellentagreement between the MCMC and ML inferences is demonstrated whereas Dollo parsimony introduces a noticeable bias in the estimations, typically yielding lower ancestral intron densities than MCMC and ML. Evolution of eukaryotic genes was dominatedbyintronloss,withsubstantialgainonlyatthebasesofseveralmajorbranchesincludingplantsandanimals. The highest intron density, 120 to 130% of the human value, is inferred for the last common ancestor of animals. The reconstruction shows that the entire line of descent from LECA to mammals was intron-rich, a state conducive to the evolutionofalternativesplicing. Citation: Csuros M, Rogozin IB, Koonin EV (2011) A Detailed History of Intron-rich Eukaryotic Ancestors Inferred from a Global Survey of 100 Complete Genomes.PLoSCom