A Feedback Quenched Oscillator Produces Turing Patterning with One Diffuser 英文参考文献.docVIP

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A Feedback Quenched Oscillator Produces Turing Patterning with One Diffuser 英文参考文献.doc

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A Feedback Quenched Oscillator Produces Turing Patterning with One Diffuser 英文参考文献

AFeedbackQuenchedOscillatorProducesTuring PatterningwithOneDiffuser JustinHsia*,WilliamJ.Holtz,DanielC.Huang,MuratArcak,MichelM.Maharbiz DepartmentofElectricalEngineeringandComputerSciences,UniversityofCalifornia,Berkeley,California,UnitedStatesofAmerica Abstract Efforts to engineer synthetic gene networks that spontaneously produce patterning in multicellular ensembles have focused on Turing’soriginal model andthe ‘‘activator-inhibitor’’ models of Meinhardt andGierer. Systems based on this modelarenotoriouslydifficulttoengineer.WepresentthefirstdemonstrationthatTuringpatternformationcanariseina new family of oscillator-driven gene network topologies, specifically when a second feedback loop is introduced which quenchesoscillationsandincorporatesadiffusiblemolecule.Weprovideananalysisofthesystemthatpredictstherangeof kinetic parameters over which patterning should emerge and demonstrate the system’s viability using stochastic simulationsofafieldofcellsusingrealisticparameters.Theprimarygoalofthispaperistoprovideacircuitarchitecture which can be implemented with relative ease by practitioners and which could serve as a model system for pattern generation in synthetic multicellular systems. Given the wide range of oscillatory circuits in natural systems, our system supportsthetantalizingpossibilitythatTuringpatternformationinnaturalmulticellularsystemscanarisefromoscillator- drivenmechanisms. Citation:HsiaJ,HoltzWJ,HuangDC,ArcakM,MaharbizMM(2012)AFeedbackQuenchedOscillatorProducesTuringPatterningwithOneDiffuser.PLoSComput Biol8(1):e1002331.doi:10.1371/journal.pcbi.1002331 Editor:MarkS.Alber,UniversityofNotreDame,UnitedStatesofAmerica ReceivedJune28,2011;AcceptedNovember14,2011;PublishedJanuary26,2012 Copyright:?2012Hsiaetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwasfundedinpartbytheNatio