A Genetic Basis for a Postmeiotic X Versus Y Chromosome Intragenomic Conflict in the Mouse 英文参考文献.docVIP
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A Genetic Basis for a Postmeiotic X Versus Y Chromosome Intragenomic Conflict in the Mouse 英文参考文献
AGeneticBasisforaPostmeioticXVersusY
ChromosomeIntragenomicConflictintheMouse
JulieCocquet1,2,3*,PeterJ.I.Ellis4,ShanthaK.Mahadevaiah5,NabeelA.Affara4,DanielVaiman1,2,3,
PaulS.Burgoyne5
1Inserm,U1016,InstitutCochin,Paris,France,2CNRS,UMR8104,Paris,France,3Universite′ParisDescartes,SorbonneParisCite′,Paris,France,4DepartmentofPathology,
MammalianMolecularGeneticsGroup,UniversityofCambridge,Cambridge,UnitedKingdom,5DivisionofStemCellBiologyandDevelopmentalGenetics,MRCNational
InstituteforMedicalResearch,London,UnitedKingdom
Abstract
Intragenomicconflictsarisewhenageneticelementfavoursitsowntransmissiontothedetrimentofothers.Conflictsover
sexchromosometransmissionareexpectedtohaveinfluencedgenomestructure,generegulation,andspeciation.Inthe
mouse,theexistenceofanintragenomicconflictbetweenX-andY-linkedmulticopygeneshaslongbeensuggestedbut
never demonstrated. The Y-encoded multicopy gene Sly has been shown to have a predominant role in the epigenetic
repression of post meiotic sex chromatin (PMSC) and, as such, represses X and Y genes, among which are its X-linked
homologsSlxandSlxl1.Here,weproducedmicethataredeficientforbothSlyandSlx/Slxl1andobservedthatSlx/Slxl1has
anoppositeroletothatofSly,inthatitstimulatesXYgeneexpressioninspermatids.Slx/Slxl1deficiencyrescuesthesperm
differentiationdefectsandnearsterilitycausedbySlydeficiencyandviceversa.Slx/Slxl1deficiencyalsocausesasexratio
distortiontowardstheproductionofmaleoffspringthatiscorrectedbySlydeficiency.Allinall,ourdatashowthatSlx/Slxl1
andSlyhaveantagonisticeffectsduringspermdifferentiationandareinvolvedinapostmeioticintragenomicconflictthat
causes segregation distortion and male sterility. This is undoubtedly what drove the massive gene amplification on the
mouseXandYchromosomes.ItmayalsobeatthebasisofcasesofF1malehybridsterilitywherethebalancebetweenSlx/
Slxl1 and Sly copy number, and therefore expression, is disrupted. To the best of our knowledge, our work is the first
demonstrationofacompetitionoccurringbetwee
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