A Genome-Wide Analysis of Promoter-Mediated Phenotypic Noise in Escherichia coli 英文参考文献.docVIP
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A Genome-Wide Analysis of Promoter-Mediated Phenotypic Noise in Escherichia coli 英文参考文献
AGenome-WideAnalysisofPromoter-Mediated
PhenotypicNoiseinEscherichiacoli
OlinK.Silander1,2,3*,NelaNikolic2,3,AlonZaslaver4,AnatBren5,IlyaKikoin5,UriAlon5 ,Martin
Ackermann2,3
1Computational and Systems Biology, Biozentrum, University of Basel, Basel, Switzerland, 2Department of Environmental Sciences, Eidgeno¨ssische Technische
Hochschule(ETH)Zurich,Zurich,Switzerland,3DepartmentofEnvironmentalMicrobiology,Eawag,Dubendorf,Switzerland,4DivisionofBiology,CaliforniaInstituteof
Technology,Pasadena,California,UnitedStatesofAmerica,5DepartmentofMolecularCellBiologyandDepartmentofPhysicsofComplexSystems,WeizmannInstitute
ofScience,Rehovot,Israel
Abstract
Gene expression is subject to random perturbations that lead to fluctuations in the rate of protein production. As a
consequence,foranygivenprotein,geneticallyidenticalorganismslivinginaconstantenvironmentwillcontaindifferent
amountsofthatparticularprotein,resultingindifferentphenotypes.Thisphenomenonisknownas‘‘phenotypicnoise.’’In
bacterial systems, previous studies have shown that, for specific genes, both transcriptional and translational processes
affect phenotypic noise. Here, we focus on how the promoter regions of genes affect noise and ask whether levels of
promoter-mediated noise are correlated with genes’ functional attributes, using data for over 60% of all promoters in
Escherichiacoli.Wefindthatessentialgenesandgeneswithahighdegreeofevolutionaryconservationhavepromoters
that confer low levels of noise. We also find that the level of noise cannot be attributed to the evolutionary time that
differentgeneshavespentinthegenomeofE.coli.Incontrasttopreviousresultsineukaryotes,wefindnoassociation
betweenpromoter-mediatednoiseandgeneexpressionplasticity.Theseresultsareconsistentwiththehypothesisthat,in
bacteria,naturalselectioncanacttoreducegeneexpressionnoiseandthatsomeofthisnoiseiscontrolledthroughthe
sequenceofthepromoterregionalone.
Citation:SilanderOK,NikolicN,ZaslaverA,BrenA,KikoinI,etal.(2012)AGenome-WideAnalysi
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