A Genome-Wide SNP Scan Reveals Novel Loci for Egg Production and Quality Traits in White Leghorn and Brown-Egg Dwarf Layers 英文参考文献.docVIP

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A Genome-Wide SNP Scan Reveals Novel Loci for Egg Production and Quality Traits in White Leghorn and Brown-Egg Dwarf Layers 英文参考文献.doc

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A Genome-Wide SNP Scan Reveals Novel Loci for Egg Production and Quality Traits in White Leghorn and Brown-Egg Dwarf Layers 英文参考文献

AGenome-WideSNPScanRevealsNovelLociforEgg ProductionandQualityTraitsinWhiteLeghornand Brown-EggDwarfLayers WenboLiu,DongfengLi,JianfengLiu,SiruiChen,LujiangQu,JiangxiaZheng,GuiyunXu,NingYang* National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China AgriculturalUniversity,Beijing,China Abstract Availability of the complete genome sequence as well as high-density SNP genotyping platforms allows genome-wide associationstudies(GWAS)inchickens.Ahigh-densitySNParraycontaining57,636markerswasemployedhereintoidentify associatedvariantsunderlyingeggproductionandqualitytraitswithintwolinesofchickens,i.e.,WhiteLeghornandbrown- eggdwarflayers.Foreachindividual,ageatfirstegg(AFE),firsteggweight(FEW),andnumberofeggs(EN)from21to56 weeksofagewererecorded,andeggqualitytraitsincludingeggweight(EW),eggshellweight(ESW),yolkweight(YW), eggshell thickness (EST), eggshell strength (ESS), albumen height(AH) and Haugh unit(HU) were measured at 40 and 60 weeksofage.Atotalof385WhiteLeghornfemalesand361brown-eggdwarfdamswereselectedtobegenotyped.The genome-widescanrevealed8SNPsshowinggenome-wisesignificant(P,1.51E-06,Bonferronicorrection)associationwith eggproductionandqualitytraits undertheFisher’s combinedprobability method.SomesignificantSNPsarelocatedin knowngenesincludingGRB14andGALNT1thatcanimpactdevelopmentandfunctionofovary,butmorearelocatedin geneswithunclearfunctionsinlayers,andneedtobestudiedfurther.Manychromosome-wisesignificantSNPswerealso detectedinthisstudyandsomeofthemarelocatedinpreviouslyreportedQTLregions.Mostoflocidetectedinthisstudy arenovelandthefollow-upreplicationstudiesmaybeneededtofurtherconfirmthefunctionalsignificanceforthesenewly identifiedSNPs. Citation:LiuW,LiD,LiuJ,ChenS,QuL,etal.(2011)AGenome-WideSNPScanRevealsNovelLociforEggProductionandQualityTraitsinWhiteLeghornand Brown-EggDwarfLayers.PLoSONE6(12):e28600.doi:10.1371/journal.pone.0028600 Editor:AlanChristo