A Higher Correlation of HCV Core Antigen with CD4+ T Cell Counts Compared with HCV RNA in HCVHIV-1 Coinfected Patients 英文参考文献.docVIP

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A Higher Correlation of HCV Core Antigen with CD4+ T Cell Counts Compared with HCV RNA in HCVHIV-1 Coinfected Patients 英文参考文献.doc

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AHigherCorrelationofHCVCoreAntigenwithCD4TCellCountsComparedwithHCVRNAinHCVHIV-1CoinfectedPatients英文参考文献

AHigherCorrelationofHCVCoreAntigenwithCD4+T CellCountsComparedwithHCVRNAinHCV/HIV-1 CoinfectedPatients TaoShen1.,XiangmeiChen1.,WeidongZhang2,YuanlinXi2,GuanghuaCao3,YuhongZhi4 ,Shuiwang Wang4,ChunhuiXu1,LaiWei5,FengminLu1*,HuiZhuang1* 1DepartmentofMicrobiologyandInfectiousDiseaseCenter,PekingUniversityHealthScienceCenter,Beijing,China,2DepartmentofEpidemiology,CollegeofPublic Health, Zhengzhou University, Zhengzhou, Henan, China, 3Shangcai County People’s Hospital, Shangcai, Henan, China, 4Shangcai Center for Disease Control and Prevention,Shangcai,Henan,China,5InstituteofHepatology,PekingUniversityPeople’sHospital,Beijing,China Abstract DevelopmentofHCVinfectionistypicallyfollowedbychronichepatitisC(CHC)inmostpatients,whilespontaneousHCV viralclearance(SVC)occursinonlyaminorityofsubjects.ComparedwiththewidespreadapplicationofHCVRNAtestingby quantitativeRT-PCRtechnique,HCVcoreantigendetectionmaybeanalternativeindicatorinthediagnosisofhepatitisC virus infections andin monitoringthestatus ofinfectious individuals. However, thecorrelation anddifferencesbetween thesetwoindicatorsinHCVinfectionneedmoreinvestigation,especiallyinpatientscoinfectedbyHIV-1.Inthisstudy,a totalof354anti-HCVand/oranti-HIVserumpositiveresidentsfromavillageofcentralChinawereenrolled.BesidesHCV- related hepatopathic variables including clinical status, ALT, AST, anti-HCV Abs, as well as the altered CD4+/CD8+ T cell counts,HCVcoreantigenandHCVviralloadwerealsomeasured.TheconcentrationofserumHCVcoreantigenwashighly correlated with level of HCV RNA in CHC patients with or without HIV-1 coinfection. Of note, HCV core antigen concentrationwasnegativelycorrelatedwithCD4+Tcellcount,whilenocorrelationwasfoundbetweenHCVRNAleveland CD4+Tcellcount.OurfindingssuggestedthatquantitativedetectionofplasmaHCVcoreantigenmaybeanalternative indicator of HCV RNA qPCR assay when evaluating the association between HCV replication and host immune status in HCV/HIV-1coinfectedpatients. Citation:ShenT,ChenX,ZhangW,XiY,C