A Mismatch-Based Model for Memory Reconsolidation and Extinction in Attractor Networks 英文参考文献.docVIP

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A Mismatch-Based Model for Memory Reconsolidation and Extinction in Attractor Networks 英文参考文献.doc

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A Mismatch-Based Model for Memory Reconsolidation and Extinction in Attractor Networks 英文参考文献

AMismatch-BasedModelforMemoryReconsolidation andExtinctioninAttractorNetworks RemusOsan1,2,3.,AdrianoB.L.Tort4,5.,OlavoB.Amaral6* 1Center for Neuroscience, Boston University, Boston, Massachusetts, United States of America, 2Center for Biodynamics, Boston University, Boston, Massachusetts, United States of America, 3Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States of America, 4Brain Institute, Federal UniversityofRioGrandedoNorte,Natal,RioGrandedoNorte,Brazil,5EdmondandLilySafraInternationalInstituteofNeuroscienceofNatal,Natal,RioGrandedoNorte, Brazil,6InstituteofMedicalBiochemistry,FederalUniversityofRiodeJaneiro,RiodeJaneiro,Brazil Abstract The processes of memory reconsolidation and extinction have received increasing attention in recent experimental research,astheirpotentialclinicalapplicationsbegintobeuncovered.Anumberofstudiessuggestthatamnesticdrugs injected after reexposure to a learning context can disrupt either of the two processes, depending on the behavioral protocolemployed.Hypothesizingthatreconsolidationrepresentsupdatingofamemorytraceinthehippocampus,while extinction represents formation of a new trace, we have built a neural network model in which either simple retrieval, reconsolidation or extinction of a stored attractor can occur upon contextual reexposure, depending on the similarity between the representations of the original learning and reexposure sessions. This is achieved by assuming that independent mechanisms mediate Hebbian-like synaptic strengthening and mismatch-driven labilization of synaptic changes,withproteinsynthesisinhibitionpreferentiallyaffectingtheformer.Ourframeworkprovidesaunifiedmechanistic explanationforexperimentaldatashowing(a)theeffectofreexposuredurationontheoccurrenceofreconsolidationor extinctionand(b)therequirementofmemoryupdatingduringreexposuretodrivereconsolidation. Citation:OsanR,TortABL,AmaralOB(2011)AMismatch-BasedModelforMemoryReconsolidationandExtinctioninA