A Model-Based Analysis of Chemical and Temporal Patterns of Cuticular Hydrocarbons in Male Drosophila melanogaster 英文参考文献.docVIP

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A Model-Based Analysis of Chemical and Temporal Patterns of Cuticular Hydrocarbons in Male Drosophila melanogaster 英文参考文献.doc

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A Model-Based Analysis of Chemical and Temporal Patterns of Cuticular Hydrocarbons in Male Drosophila melanogaster 英文参考文献

AModel-BasedAnalysisofChemicalandTemporal PatternsofCuticularHydrocarbonsinMaleDrosophila melanogaster ClementKent,RezaAzanchi,BenSmith¤,AdrienneChu,JoelLevine* DepartmentofBiology,UniversityofTorontoatMississauga,Mississauga,Ontario,Canada Drosophila Cuticular Hydrocarbons (CH) influence courtship behaviour, mating, aggregation, oviposition, and resistance to desiccation.Wemeasuredlevelsof24differentCHcompoundsofindividualmaleD.melanogasterhourlyunderavarietyof environmental(LD/DD)conditions.Usingamodel-basedanalysisofCHvariation,wedevelopedanimprovednormalization methodforCHdata,andshowthatCHcompoundshavereproduciblecyclicwithin-daytemporalpatternsofexpressionwhich differ between LD and DD conditions. Multivariate clustering of expression patterns identified 5 clusters of co-expressed compounds with common chemical characteristics. Turnover rate estimates suggest CH production may be a significant metaboliccost.Malecuticularhydrocarbonexpressionisadynamictraitinfluencedbylightandtimeofday;sinceabundant hydrocarbons affect male sexual behavior, males may present different pheromonal profiles at different times and under differentconditions. Citation: KentC,AzanchiR,SmithB,ChuA,LevineJ(2007)AModel-BasedAnalysisofChemicalandTemporalPatternsofCuticularHydrocarbonsin MaleDrosophilamelanogaster.PLoSONE2(9):e962.doi:10.1371/journal.pone.0000962 INTRODUCTION In order to study daily variation in these compounds we have hadtoreviewmethodsforanalyzingthesecompounds.Wehave characterizedthesemethodsandidentifiedanunderlyinggeneral linearmodelofcuticularhydrocarbonabundanceswhichexplains a higher percent of variance than previous methods. The model canbeusedtodeducenewfeaturesofCHvariation,butperhaps itsmostimportantapplicationistoanormalizationmethodwhich considerablyreduceserrorvariancesinCHmeasurements. Using our model-based analysis, we show that there are five clusters of compounds whose abundance patterns co-vary, and that membership of these clusters is a function of c