A Lactobacillus rhamnosus Strain Induces a Heme Oxygenase Dependent Increase in Foxp3+ Regulatory T Cells 英文参考文献.docVIP

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A Lactobacillus rhamnosus Strain Induces a Heme Oxygenase Dependent Increase in Foxp3+ Regulatory T Cells 英文参考文献.doc

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ALactobacillusrhamnosusStrainInducesaHemeOxygenaseDependentIncreaseinFoxp3RegulatoryTCells英文参考文献

ALactobacillusrhamnosusStrainInducesaHeme OxygenaseDependentIncreaseinFoxp3+RegulatoryT Cells KhalilKarimi1,3*,NalaayiniKandiah1,JessieChau1,3,JohnBienenstock1,4,PaulForsythe1,2,3 * 1TheBrainBodyinstitute,McMasterUniversity,Hamilton,Ontario,Canada,2FirestoneInstituteforRespiratoryHealth,McMasterUniversity,Hamilton,Ontario,Canada, 3DepartmentofMedicine,McMasterUniversity,Hamilton,Ontario,Canada,4DepartmentofPathologyandMolecularMedicine,McMasterUniversity,Hamilton,Ontario, Canada Abstract WeinvestigatedtheconsequencesoffeedingwithaLactobacillusspeciesontheimmuneenvironmentinGALT,andthe roleofdendriticcellsandhemeoxygenase-1inmediatingtheseresponses.FeedingwithaspecificstrainofLactobacillus rhamnosus induced a significant increase in CD4+CD25+Foxp3+ functional regulatory T cells in GALT. This increase was greatestinthemesentericlymphnodesandassociatedwithamarkeddecreaseinTNFandIFNcproduction.Dendriticcell regulatory function and HO-1 expression was also increased. The increase in Foxp3+ T cells could be prevented by treatmentwithahemeoxygenaseinhibitor.However,neitherinhibitionofhemeoxygenasenorblockadeofIL-10andTGFb prevented the inhibition of inflammatory cytokine production. In conclusion Lactobacillus feeding induced a tolerogenic environmentinGALT.HO-1wascriticaltotheenhancementofFoxp3+regulatoryTcellswhileadditional,asyetunknown, pathwayswereinvolvedinthedown-regulationofinflammatorycytokineproductionbyTcells. Citation: Karimi K, Kandiah N, Chau J, Bienenstock J, Forsythe P (2012) A Lactobacillus rhamnosus Strain Induces a Heme Oxygenase Dependent Increase in Foxp3+RegulatoryTCells.PLoSONE7(10):e47556.doi:10.1371/journal.pone.0047556 Editor:CiriacoA.Piccirillo,McGillUniversityHealthCenter,Canada ReceivedMarch21,2012;AcceptedSeptember18,2012;PublishedOctober15,2012 Copyright: ? 2012 Karimi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninany