A Population-Based Study of Gastroesophageal Reflux Disease and Sleep Problems in Elderly Twins 英文参考文献.docVIP

下载本文档

0
0
约3.54万字
约 7页
2017-05-11 发布于上海
举报
版权申诉

A Population-Based Study of Gastroesophageal Reflux Disease and Sleep Problems in Elderly Twins 英文参考文献.doc

1、本文档共7页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

A Population-Based Study of Gastroesophageal Reflux Disease and Sleep Problems in Elderly Twins 英文参考文献

APopulation-BasedStudyofGastroesophagealReflux DiseaseandSleepProblemsinElderlyTwins AnnaLindam1*,CatarinaJansson2,HelenaNordenstedt1,NancyL.Pedersen3,JesperLagergren1,4 1UnitofUpperGastrointestinalResearch,DepartmentofMolecularMedicineandSurgery,KarolinskaInstitutet,Stockholm,Sweden,2DivisionofInsuranceMedicine, DepartmentofClinicalNeuroscience,KarolinskaInstitutet,Stockholm,Sweden,3DepartmentofMedicalEpidemiologyandBiostatistics,KarolinskaInstitutet,Stockholm, Sweden,4DivisionofCancerStudies,KingsCollegeLondon,London,UnitedKingdom Abstract BackgroundAims:Previousstudiesindicateanassociationbetweensleepproblemsandgastroesophagealrefluxdisease (GERD). Although both these conditions separately have moderate heritabilities, confounding by genetic factors has not previouslybeentakenintoaccount.ThisstudyaimedtorevealtheassociationbetweensleepproblemsandGERD,while adjustingforheredityandotherpotentialconfoundingfactors. Methods:Thiscross-sectionalpopulation-basedstudyincludedall8,014same-sexedtwinsofatleast65yearsofageand borninSwedenbetween1886and1958,whoparticipatedintelephoneinterviewsin1998–2002.Threelogisticregression modelswereused1)externalcontrolanalysis,2)within-pairco-twinanalysiswithdizygotic(DZ)twinpairsdiscordantfor GERD,and3)within-pairco-twinanalysiswithmonozygotic(MZ)twinpairsdiscordantforGERD.Oddsratios(ORs)with95% confidenceintervals(CIs)werecalculatedandadjustedforestablishedriskfactorsforGERD,i.e.sex,age,bodymassindex (BMI),tobaccosmoking,andeducationallevel. Results:Adose-responseassociationwasidentifiedbetweenincreasinglevelsofsleepproblemsandGERDintheexternal controlanalysis.Individualswhooftenexperiencedsleepproblemshadatwo-foldincreasedoccurrenceofGERDcompared tothosewhoseldomhadsleepproblems(OR2.0,95%CI1.8–2.4).Thecorrespondingassociationwasofsimilarstrengthin theco-twinanalysisincluding356DZpairs(OR2.2,95%CI1.6–3.4),andintheco-twinanalysisincluding210MZpairs(OR 1.5,95%CI0.9–2.7). Conclusion: A dose-dependent association between sleep problems