A Portrait of the Transcriptome of the Neglected Trematode, Fasciola gigantica—Biological and Biotechnological Implications 英文参考文献.docVIP

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A Portrait of the Transcriptome of the Neglected Trematode, Fasciola gigantica—Biological and Biotechnological Implications 英文参考文献.doc

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A Portrait of the Transcriptome of the Neglected Trematode, Fasciola gigantica—Biological and Biotechnological Implications 英文参考文献

APortraitoftheTranscriptomeoftheNeglected Trematode,Fasciolagigantica—Biologicaland BiotechnologicalImplications NeilD.Young1*,AaronR.Jex1,CinziaCantacessi1,RossS.Hall1,BronwynE.Campbell1,TerenceW. Spithill2,SirikachornTangkawattana3,PrasarnTangkawattana4,ThewarachLaha5,RobinB.Gasser1* 1DepartmentofVeterinaryScience,TheUniversityofMelbourne,Werribee,Australia,2SchoolofAnimalandVeterinarySciences,CharlesSturtUniversity,WaggaWagga, Australia,3DepartmentofPathobiology,FacultyofVeterinary,Medicine,KhonKaenUniversity,KhonKaen,Thailand,4DepartmentofAnatomy,FacultyofVeterinary Medicine,KhonKaenUniversity,KhonKaen,Thailand,5DepartmentofParasitology,FacultyofMedicine,KhonKaenUniversity,KhonKaen,Thailand Abstract Fasciolagigantica(Digenea)isanimportantfoodbornetrematodethatcausesliverflukedisease(fascioliasis)inmammals, includingungulatesandhumans,mainlyintropicalclimaticzonesoftheworld.Despiteitssocioeconomicimpact,almost nothing is known about the molecular biology of this parasite, its interplay with its hosts, and the pathogenesis of fascioliasis. Modern genomic technologies now provide unique opportunities to rapidly tackle these exciting areas. The presentstudyreportsthefirsttranscriptomerepresentingtheadultstageofF.gigantica(ofbovidorigin),definedusinga massivelyparallelsequencing-coupledbioinformaticapproach.From.20millionrawsequencereads,.30,000contiguous sequences were assembled, of which most were novel. Relative levels of transcription were determined for individual molecules, which were also characterized (at the inferred amino acid level) based on homology, gene ontology, and/or pathwaymapping.ComparisonsofthetranscriptomeofF.giganticawiththoseofothertrematodes,includingF.hepatica, revealed similarities in transcription for molecules inferred to have key roles in parasite-host interactions. Overall, the present dataset should provide a solid foundation for future fundamental genomic, proteomic, and metabolomic explorations of F. gigantica, as well as a basis f