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A Smell That Causes Seizure 英文参考文献
ASmellThatCausesSeizure
MinhQ.Nguyen*,NicholasJ.P.Ryba
TasteandSmellSection,LaboratoryofSensoryBiology,NationalInstituteofDentalandCraniofacialResearch,NationalInstitutesofHealth,Bethesda,Maryland,United
StatesofAmerica
Abstract
Inmammals,odorantsaredetectedbyalargefamilyofreceptorsthatareeachexpressedinjustasmallsubsetofolfactory
sensoryneurons(OSNs).Herewedescribeastrainoftransgenicmiceengineeredtoexpressanoctanalreceptorinalmostall
OSNs.Remarkably,octanaltriggeredastrikingandinvoluntaryphenotypeintheseanimals,withpassiveexposureregularly
inducing seizures. Octanal exposure invariably resulted in widespread activation of OSNs but interestingly seizures only
occurredin30–40%oftrials.Wehypothesizedthatthisreflectstheneedfortheolfactorysystemtofilterstrongbutslowly-
changing backgrounds from salient signals. Therefore we used an olfactometer to control octanal delivery and
demonstratedsuppressionofresponseswheneverthisodorantisdeliveredslowly.Bycontrast,rapidexposureofthemice
tooctanalinducedseizureineverytrial.Ourresultsexposenewdetailsofolfactoryprocessingandprovidearobustand
non-invasiveplatformforstudyingepilepsy.
Citation:NguyenMQ,RybaNJP(2012)ASmellThatCausesSeizure.PLoSONE7(7):e41899.doi:10.1371/journal.pone.0041899
Editor:HiroakiMatsunami,DukeUniversity,UnitedStatesofAmerica
ReceivedFebruary28,2012;AcceptedJune29,2012;PublishedJuly27,2012
Thisisanopen-accessarticle,freeofallcopyright,andmaybefreelyreproduced,distributed,transmitted,modified,builtupon,orotherwiseusedbyanyonefor
anylawfulpurpose.TheworkismadeavailableundertheCreativeCommonsCC0publicdomaindedication.
Funding:ThisresearchwassupportedbytheintramuralresearchprogramoftheUnitedStatesNationalInstitutesofHealthandNationalInstituteofDentaland
CraniofacialResearchtoN.J.P.R.Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript.
CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist.
*E-mail:mqnguyen@
Introduction
Recently, a mouse with
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