A Systematic Analytic Approach to Pandemic Influenza Preparedness Planning 英文参考文献.docVIP

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A Systematic Analytic Approach to Pandemic Influenza Preparedness Planning 英文参考文献.doc

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A Systematic Analytic Approach to Pandemic Influenza Preparedness Planning 英文参考文献

Open access, freely available online Policy Forum A Systematic Analytic Approach to Pandemic In?uenza Preparedness Planning Daniel J. Barnett*, Ran D. Balicer, Daniel R. Lucey, George S. Everly, Jr., Saad B. Omer, Mark C. Steinhoff, Itamar Grotto T The urgent need for comprehensive pandemic in?uenza planning is profound: an in?uenza pandemic starting today may have major international consequences, including global economic and political destabilization, an overwhelming of health care resources, and panic [21]. Current international plans [18,22], he prospect of a pandemic with avian in?uenza is an urgent concern for public health an updated plan is anticipated by September 2005. leaders worldwide [1]. As pathogenic avian in?uenza A (H5N1) strains (Figure 1) continue to spread in East Asia, with recently reported expansion to Siberia and westward regions in Russia [2,3] as well as to migratory birds [4,5], the risk for reassortment of avian and human strains increases. Evidence cited by the World Health Organization in May 2005 suggests that H5N1 may be adapting to humans, thus potentially setting the stage for the next in?uenza pandemic [6]. DOI: 10.1371/journal.pmed.0020359.g001 Figure 1. Colorized Transmission Electron Micrograph of Avian In?uenza A H5N1 Viruses Grown in MDCK Cells The viruses are gold, and the MDCK cells are green. Citation: Barnett DJ, Balicer RD, Lucey DR, Everly GS Jr, Omer SB, et al. (2005) A systematic analytic approach to pandemic in?uenza preparedness planning. PLoS Med 2(12): e359. Animal data suggest that the current H5N1 strain appears to be even more deadly than the original 1997 Hong Kong avian in?uenza, a ?nding that correlates well with the observed Copyright: ? 2005 Barnett et al.This is an open- access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (Photo: CDC/C. Gold