Aberrant DNA Methylation of OLIG1, a Novel Prognostic Factor in Non-Small Cell Lung Cancer 英文参考文献.docVIP

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Aberrant DNA Methylation of OLIG1, a Novel Prognostic Factor in Non-Small Cell Lung Cancer 英文参考文献.doc

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Aberrant DNA Methylation of OLIG1, a Novel Prognostic Factor in Non-Small Cell Lung Cancer 英文参考文献

o PL SMEDICINE AberrantDNAMethylationofOLIG1, aNovelPrognosticFactorin Non-SmallCellLungCancer Romulo M.Brena1,2,Carl Morrison3,Sandya Liyanarachchi2,David Jarjoura4,Ramana V.Davuluri2, Gregory A.Otterson5,David Reisman6,Selina Glaros6,Laura J.Rush7,Christoph Plass2* 1DepartmentofMolecularGenetics,TheOhioStateUniversity,Columbus,Ohio,UnitedStatesofAmerica,2DepartmentofMolecularVirology,ImmunologyandMedical Genetics,DivisionofHumanCancerGenetics,TheOhioStateUniversity,Columbus,Ohio,UnitedStatesofAmerica,3DepartmentofPathology,TheOhioStateUniversity, Columbus,Ohio,UnitedStatesofAmerica,4DivisionofBiostatistics,CollegeofMedicineandPublicHealth,TheOhioStateUniversity,Columbus,Ohio,UnitedStatesof America, 5Department ofInternal Medicine, Division ofHematology and Oncology, College ofMedicine andPublicHealth, TheOhioStateUniversity,Columbus,Ohio, UnitedStatesofAmerica,6DepartmentofInternalMedicine,DivisionofHematologyandOncology,UniversityofMichigan,AnnArbor,Michigan,UnitedStatesofAmerica, 7DepartmentofVeterinaryBiosciencesandtheComprehensiveCancerCenter,TheOhioStateUniversityColumbus,Ohio,UnitedStatesofAmerica Funding:Theresearchinthis manuscriptwassupportedinpartby fundsprovidedbytheNationalLung CancerPartnership(formerly, ABSTRACT Background WomenAgainstLungCancer Foundation)(RMB,CP),theNational CancerInstitute(NCI)grantP30 CA16058(CP),theV-Foundation, andNIH/NCIgrantCA098317(LJR). Thefundershadnoroleinstudy design,datacollectionandanalysis, decisiontopublish,orpreparation ofthemanuscript. Lungcanceristheleadingcauseofcancer-relateddeathworldwide.Currently,tumor,node, metastasis(TNM)staging providesthemostaccurateprognosticparameter forpatientswith non-small cell lung cancer (NSCLC). However, the overall survival of patients with resectable tumors varies significantly, indicating the need for additional prognostic factors to better predicttheoutcomeofthedisease,particularlywithinagivenTNMsubset. CompetingInterests:Theauthors havedeclaredthatnocompeting interes