CYP450ProteinAssay–Human.PDFVIP

CYP450 Protein Assay – Human Induction Kit Quantitation of Cytochrome P450 Protein Isoforms using an AB SCIEX Triple Quad™ or QTRAP® System Brian Williamson, Lydia Nuwaysir and Christie Hunter AB SCIEX, USA Cytochrome P450 proteins (CYPs) are major drug metabolizing enzymes responsible for phase I biotransformations (Figure 1). For pharmaceutical companies, measurement of CYP induction in response to a drug candidate is a fundamental aspect of assessing drug-drug interactions, and evaluating drug safety and efficacy. There are currently three main methodologies for assessing CYP450