Abundance and Diversity of Dockerin-Containing Proteins in the Fiber-Degrading Rumen Bacterium, Ruminococcus flavefaciens FD-1 英文参考文献.docVIP

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Abundance and Diversity of Dockerin-Containing Proteins in the Fiber-Degrading Rumen Bacterium, Ruminococcus flavefaciens FD-1 英文参考文献.doc

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Abundance and Diversity of Dockerin-Containing Proteins in the Fiber-Degrading Rumen Bacterium, Ruminococcus flavefaciens FD-1 英文参考文献

AbundanceandDiversityofDockerin-Containing ProteinsintheFiber-DegradingRumenBacterium, RuminococcusflavefaciensFD-1 MarcoT.Rincon1.,BareketDassa2.,HarryJ.Flint1*,AnthonyJ.Travis1,SadanariJindou3,IlyaBorovok3, RaphaelLamed3,EdwardA.Bayer2,BernardHenrissat4,PedroM.Coutinho4,DionA.Antonopoulos5, MargretE.BergMiller5,BryanA.White5 1Microbial Ecology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom, 2Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel, 3Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel, 4Architecture et FonctiondesMacromoleculesBiologiques,CNRSandUniversitesd’Aix-MarseilleIII,Marseille,France,5DivisionofNutritionalSciences,DepartmentofAnimalSciences, NorthAmericanConsortiumforGenomicsofFibrolyticRuminalBacteria,UniversityofIllinois,Urbana,Illinois,UnitedStatesofAmerica Abstract Background: Thecellulosomeisamulti-enzymemachine,whichplaysakeyroleinthebreakdownofplantcellwallsin many anaerobic cellulose-degrading microorganisms. Ruminococcus flavefaciens FD-1, a major fiber-degrading bacterium presentinthegutofherbivores,hasthemostintricatecellulosomalorganizationthusfardescribed.Cellulosomecomplexes are assembled through high-affinity cohesin-dockerin interactions. More than two-hundred dockerin-containing proteins have been identified in the R. flavefaciens genome, yet the reason for the expansion of these crucial cellulosomal componentsisyetunknown. Methodology/Principal Findings: We have explored the full spectrum of 222 dockerin-containing proteins potentially involved in the assembly of cellulosome-like complexes of R. flavefaciens. Bioinformatic analysis of the various dockerin modulesshoweddistinctiveconservationpatternswithintheirtwoCa -bindingrepeatsandtheirflankingregions.Thus, 2+ we established the conceptual framework for six major groups of dockerin types, according to their unique sequence features. Within t