FittingMarginalStructuralModels.pptVIP

Fitting Marginal Structural Models Eleanor M Pullenayegum Asst Professor Dept of Clin. Epi Biostatistics pullena@mcmaster.ca  Outline Causality and observational data Inverse-Probability weighting and MSMs Fitting an MSM Goodness-of-fit Assumptions/ Interpretation Causality in Medical Research Often want to establish a causal association between a treatment/exposure and an event Difficult to do with observational data due to confounding Gold-standard for causal inferences is the randomized trial Randomize half the patients to receive the treatment/exposure, and half to receive usual care D