ProteinSecondaryStructurePrediction.pptVIP

Protein Secondary Structure Prediction Outline What is Secondary Structure Introduction to Secondary Structure Prediction Chou-Fasman Method Nearest Neighbor Method Neural Network Method Structures in Protein Language: Letters ? Words ? Sentences Protein: Residues ? Secondary Structure ?Tertiary Structure a helix b sheet -sheet (parallel, anti-parallel) Classification ofsecondary structure Defining features Dihedral angles Hydrogen bonds Geometry Assigned manually by experimentalists Automatic DSSP (Kabsch Sander,1983) STRIDE (Frishman Argos, 1995) Continuum (Andersen et al.) Classifica