ProteinStructureandFunction.PDFVIP

Protein Structure and Function I619: Structural Bioinformatics January 16, 2008 Protein Folding Problem • How do proteins fold into a specific 3-D structure? • How does the primary structure of a protein determine its secondary and tertiary structure? • there are two conditions a protein needs to meet – there must be a single, stable, folded conformation (thermodynamic condition) – a protein must fold on an appropriate time scale (kinetic condition) • th