Activity-Dependent Changes in Cholinergic Innervation of the Mouse Olfactory Bulb 英文参考文献.docVIP

Activity-Dependent Changes in Cholinergic Innervation of the Mouse Olfactory Bulb 英文参考文献.doc

  1. 1、本文档共8页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  5. 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  6. 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  7. 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  8. 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Activity-Dependent Changes in Cholinergic Innervation of the Mouse Olfactory Bulb 英文参考文献

Activity-DependentChangesinCholinergicInnervation oftheMouseOlfactoryBulb ErnestoSalcedo1,TuanTran1,XuanLy1,RobertLopez1,CortneyBarbica1,DiegoRestrepo1,3 ,Sukumar Vijayaraghavan2,3 * 1DepartmentofCellandDevelopmentalBiology,UniversityofColorado,SchoolofMedicine,Aurora,Colorado,UnitedStatesofAmerica,2DepartmentofPhysiologyand Biophysics,UniversityofColorado,SchoolofMedicine,Aurora,Colorado,UnitedStatesofAmerica,3NeuroscienceProgram,UniversityofColorado,SchoolofMedicine, Aurora,Colorado,UnitedStatesofAmerica Abstract Theinterplaybetweenolfactoryactivityandcholinergicmodulationremainstobefullyunderstood.Thisreportexamines thepatternofcholinergicinnervationthroughoutthemurinemainolfactorybulbacross differentdevelopmentalstages andinnaris-occludedanimals.Tovisualizethepatternofcholinergicinnervation,weusedatransgenicmousemodel,which expressesafusionofthemicrotubule-associatedprotein,tau,withgreenfluorescenceprotein(GFP)underthecontrolof the choline acetyltransferase (ChAT) promoter. This tau-GFP fusion product allows for a remarkably vivid and clear visualizationofcholinergicinnervationinthemainolfactorybulb(MOB).Interestingly,wefindanunevendistributionof GFP label in the adult glomerular layer (GL), where anterior, medial, and lateral glomerular regions of the bulb receive relativelyheaviercholinergicinnervationthanotherregions.Incontrasttopreviousreports,wefindamarkedchangeinthe patternofcholinergicinnervationtotheGLfollowingunilateralnaris occlusion betweentheipsilateralandcontralateral bulbsinadultanimals. Citation: Salcedo E,Tran T, Ly X,Lopez R, Barbica C, et al.(2011) Activity-Dependent Changes inCholinergic Innervation ofthe Mouse Olfactory Bulb. PLoS ONE6(10):e25441.doi:10.1371/journal.pone.0025441 Editor:HiroakiMatsunami,DukeUniversity,UnitedStatesofAmerica ReceivedApril15,2011;AcceptedSeptember5,2011;PublishedOctober28,2011 Copyright: ? 2011 Salcedo et al. This is an open-access article distributed under the terms of the Creative Commons Attributi

您可能关注的文档

文档评论(0)

1234554321 + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档