ActRIIA and BMPRII Type II BMP Receptor Subunits Selectively Required for Smad4-Independent BMP7-Evoked Chemotaxis 英文参考文献.docVIP

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ActRIIA and BMPRII Type II BMP Receptor Subunits Selectively Required for Smad4-Independent BMP7-Evoked Chemotaxis 英文参考文献.doc

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ActRIIA and BMPRII Type II BMP Receptor Subunits Selectively Required for Smad4-Independent BMP7-Evoked Chemotaxis 英文参考文献

ActRIIAandBMPRIITypeIIBMPReceptorSubunits SelectivelyRequiredforSmad4-IndependentBMP7- EvokedChemotaxis JeanetteC.Perron,JaneDodd* DepartmentsofPhysiologyandCellularBiophysicsandNeuroscience,ColumbiaUniversity,NewYork,NewYork,UnitedStatesofAmerica Abstract Bone morphogenetic protein (BMP)-evoked reorientation and chemotaxis of cells occurs with rapid onset and involves events local to the cell membrane. The signaling pathways underlying these rapid processes likely diverge from those mediatingclassical transcriptionalresponses toBMPsbut itremains unclearhow BMPreceptors areutilizedtogenerate distinct intracellular mechanisms. We show that BMP7-evoked chemotaxis of monocytic cells depends on the activity of canonical type II BMP receptors. Although the three canonical type II BMP receptors are expressed in monocytic cells, inhibitionofreceptorsubunitexpressionbyRNAirevealsthatActRIIAandBMPRII,butnotActRIIB,areeachessentialfor BMP7-evoked chemotaxis but not required individually for BMP-mediated induction. Furthermore, the chemotactic response to BMP7 does not involve canonical Smad4-dependent signaling but acts through PI3K-dependent signaling, illustratingselectiveactivationofdistinctintracellulareventsthroughdifferentialengagementofreceptors.Wesuggesta model of a BMP receptor complex in which the coordinated activity of ActRIIA andBMPRII receptor subunits selectively mediatesthechemotacticresponsetoBMP7. Citation: Perron JC, Dodd J (2009) ActRIIA and BMPRII Type II BMP Receptor Subunits Selectively Required for Smad4-Independent BMP7-Evoked Chemotaxis.PLoSONE4(12):e8198.doi:10.1371/journal.pone.0008198 Editor:EdwardGiniger,NationalInstitutesofHealth(NIH),UnitedStatesofAmerica ReceivedSeptember1,2009;AcceptedNovember15,2009;PublishedDecember8,2009 Copyright: ? 2009 Perron, Dodd. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheor