Acute Histologic Chorioamnionitis at Term Nearly Always Noninfectious 英文参考文献.docVIP

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Acute Histologic Chorioamnionitis at Term Nearly Always Noninfectious 英文参考文献.doc

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Acute Histologic Chorioamnionitis at Term Nearly Always Noninfectious 英文参考文献

AcuteHistologicChorioamnionitisatTerm:Nearly AlwaysNoninfectious DrucillaJ.Roberts1,AnnC.Celi2,LauraE.Riley3,AndrewB.Onderdonk4,TheoniaK.Boyd5, LiseCarolynJohnson6,ElliceLieberman7,8* 1DepartmentofPathology,MassachusettsGeneralHospital,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,2DivisionofGeneralMedicine, BrighamandWomen’sHospital,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,3DepartmentofObstetricsandGynecology,Massachusetts GeneralHospital,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,4ClinicalMicrobiologyLaboratory,BrighamandWomen’sHospital,Harvard MedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,5DepartmentofPathology,Children’sHospitalBoston,HarvardMedicalSchool,Boston,Massachusetts, United States of America, 6Department of Newborn Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, 7Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 8Department of Newborn Medicine,BrighamandWomen’sHospital,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica Abstract Background:Thelinkbetweenhistologicacutechorioamnionitisandinfectioniswellestablishedinpretermdeliveries,but lesswell-studiedintermpregnancies,whereinfectionismuchlesscommon. Methodology/PrincipalFindings:Weconductedasecondaryanalysisamong195low-riskwomenwithtermpregnancies enrolledinarandomizedtrial.Histologicandmicrobiologicevaluationofplacentasincludedanaerobicandaerobiccultures (including mycoplasma/ureaplasma species) as well as PCR. Infection was defined as $1,000cfu of a single known pathogen or a $2 log difference in counts for a known pathogen versus other organisms in a mixed culture. Placental membranes were scored and categorized as: no chorioamnionitis, Grade 1 (subchorionitis and patchy acute chorioamnionitis), or Grade 2 (severe, confluent chorioamnionitis). Grade 1 or grade 2 histologic chor