Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression 英文参考文献.docVIP

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Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression 英文参考文献.doc

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Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression 英文参考文献

Review AdvancingDrugInnovationforNeglectedDiseases— CriteriaforLeadProgression SolomonNwaka1*,BernadetteRamirez1,RetoBrun2,LouisMaes3,FrankDouglas4,RobertRidley1 1SpecialProgrammeforResearchandTraininginTropicalDiseases(TDR),WorldHealthOrganization,Geneva,Switzerland,2SwissTropicalInstitute,Basel,Switzerland, 3UniversityofAntwerp,Antwerp,Belgium,4EwingMarionKauffmanFoundation,KansasCity,Missouri,UnitedStatesofAmerica againstresistantparasitesandcanbesafelyadministeredtochildren andpregnantwomenareurgentlyneeded[3,10].Evenformalaria, Abstract: The current drug RD pipeline for most neglecteddiseasesremainsweak,andunlikelytosupport registrationofnoveldrugclassesthatmeetdesiredtarget productprofilesintheshortterm.Thiscallsforsustained whichhasprobablyhadsignificantinvestment,thedrugsexpected from the existing RD portfolio in the next few years are a combination of old drugs that are mostly reliant on artemisinins. investment as well as greater emphasis in the risky Going by the industrial assessment of attrition, the number of upstreamdrugdiscovery.Accesstotechnologies,resourc- projectsinthepre-clinicalphaseofRDistoosmalltoguarantee es, and strong management as well as clear compound success.RecentreportsofartemisininresistanceinAsia[11]means progression criteria are factors in the successful imple- mentationofanycollaborativedrugdiscoveryeffort.We discuss how some of these factors have impacted drug thatemphasishastobeplacedonthediscoveryofnovelentitiesto supportthemediumtolong-termneedsofmalariacontrolaswellas discovery for tropical diseases within the past four decades,andhighlightnewopportunitiesandchallenges throughthevirtualNorth–Southdrugdiscoverynetwork as well as the rationale for greater participation of institutionsindevelopingcountriesinproductinnovation. A set of criteria designed to facilitate compound progression from screening hits to drug candidate selectionispresentedtoguideongoingefforts. possible elimination and eradication. The ongoing dis