Adenovirus-Vectored Drug-Vaccine Duo as a Rapid-Response Tool for Conferring Seamless Protection against Influenza 英文参考文献.docVIP
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Adenovirus-Vectored Drug-Vaccine Duo as a Rapid-Response Tool for Conferring Seamless Protection against Influenza 英文参考文献
Adenovirus-VectoredDrug-VaccineDuoasaRapid-
ResponseToolforConferringSeamlessProtection
againstInfluenza
JianfengZhang1,E.BartTarbet2,TsungweiFeng1,ZhongkaiShi1,KentR.VanKampen1,De-chuC.
Tang1*
1Vaxin,Inc.,Birmingham,Alabama,UnitedStatesofAmerica,2InstituteforAntiviralResearch,UtahStateUniversity,Logan,Utah,UnitedStatesofAmerica
Abstract
Fewotherdiseasesexertsuchahugetollofsufferingasinfluenza.Wereportherethatintranasal(i.n.)administrationofE1/
E3-defective (DE1E3) adenovirus serotype 5 (Ad5) particles rapidly induced an anti-influenza state as a means of
prophylactictherapy whichpersistedfor severalweeksin mice.By encodinganinfluenza virus(IFV)hemagglutinin(HA)
HA1 domain, an Ad5-HA1 vector conferred rapid protection as a prophylactic drug followed by elicitation of sustained
protectiveimmunityasavaccineforinducingseamlessprotectionagainstinfluenzaasadrug-vaccineduo(DVD)inasingle
package.SinceAd5particlesinduceacomplexwebofhostresponses,whichcouldarrestinfluenzabyactivatingaspecific
armofinnateimmunitytoimpedeIFVgrowthintheairway,itisconceivablethatthismulti-prongedinfluenzaDVDmay
escapethefateofdrugresistancethatimpairsthecurrentinfluenzadrugs.
Citation: Zhang J, Tarbet EB, Feng T, Shi Z, Van Kampen KR, et al. (2011) Adenovirus-Vectored Drug-Vaccine Duo as a Rapid-Response Tool for Conferring
SeamlessProtectionagainstInfluenza.PLoSONE6(7):e22605.doi:10.1371/journal.pone.0022605
Editor:K.T.Jeang,NationalInstituteofHealth,UnitedStatesofAmerica
ReceivedMay19,2011;AcceptedJune25,2011;PublishedJuly27,2011
Copyright: ? 2011 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:ThisworkwassupportedbyNationalInstitutesofHealthgrants2-R44-AI-068285-02and1-UC1-AI-067198-01;aNationalInstitutesofHealthcontract
N01-AI-30063; and a National Institute of Allergy and Infectious Diseases Non
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