Adaptations to Submarine Hydrothermal Environments Exemplified by the Genome of Nautilia profundicola 英文参考文献.docVIP

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Adaptations to Submarine Hydrothermal Environments Exemplified by the Genome of Nautilia profundicola 英文参考文献.doc

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Adaptations to Submarine Hydrothermal Environments Exemplified by the Genome of Nautilia profundicola 英文参考文献

AdaptationstoSubmarineHydrothermalEnvironments ExemplifiedbytheGenomeofNautiliaprofundicola BarbaraJ.Campbell1*,JulieL.Smith1,ThomasE.Hanson2,MartinG.Klotz3,LisaY.Stein4¤,CharlesK. Lee5,DongyingWu6,JeffreyM.Robinson7,HodaM.Khouri7,JonathanA.Eisen6,S.CraigCary1,5 1University of Delaware, Lewes, Delaware, United States of America, 2University of Delaware, Newark, Delaware, United States of America, 3University of Louisville, Louisville,Kentucky,UnitedStatesofAmerica,4UniversityofCaliforniaRiverside,Riverside,California,UnitedStatesofAmerica,5UniversityofWaikato,Hamilton,New Zealand,6UniversityofCaliforniaDavis,Davis,California,UnitedStatesofAmerica,7TheJ.CraigVenterInstitute,Rockville,Maryland,UnitedStatesofAmerica Abstract SubmarinehydrothermalventsaremodelsystemsfortheArchaeanEarthenvironment,andsomesitesmaintainconditions thatmayhavefavoredtheformationandevolutionofcellularlife.Ventsaretypifiedbyrapidfluctuationsintemperature andredoxpotentialthatimposeastrongselectivepressureonresidentmicrobialcommunities.Nautiliaprofundicolastrain Am-Hisamoderatelythermophilic,deeply-branchingEpsilonproteobacteriumfoundfree-livingathydrothermalventsandis a member of the microbial mass on the dorsal surface of vent polychaete, Alvinella pompejana. Analysis of the 1.7-Mbp genome of N. profundicola uncovered adaptations to the vent environment—some unique and some shared with other Epsilonproteobacterial genomes. The major findings included: (1) a diverse suite of hydrogenases coupled to a relatively simpleelectrontransportchain,(2)numerousstressresponsesystems,(3)anovelpredictednitrateassimilationpathway withhydroxylamineasakeyintermediate,and(4)agene(rgy)encodingthehallmarkproteinforhyperthermophilicgrowth, reversegyrase.AdditionalexperimentsindicatedthatexpressionofrgyinstrainAm-Hwasinducedover100-foldwitha 20uCincreaseabovetheoptimalgrowthtemperatureofthisbacteriumandthatcloselyrelatedrgygenesarepresentand expressed in bacterial communities residing in geographically distinct