Adverse Events of Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound Therapy 英文参考文献.docVIP

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Adverse Events of Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound Therapy 英文参考文献.doc

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Adverse Events of Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound Therapy 英文参考文献

AdverseEventsofExtracorporealUltrasound-Guided HighIntensityFocusedUltrasoundTherapy TingheYu1,2*,JunLuo3 1Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China, 2Key Laboratory of Obstetrics and Gynecology,ChongqingBureauofHealth,Chongqing,China,3HospitalofStomatology,ChongqingMedicalUniversity,Chongqing,China Abstract Background: High-intensity focused ultrasound (HIFU) is considered to be an alternative to surgery. Extracorporeal ultrasound-guided HIFU (USgFU) has been clinically used to treat solid tumors. Preliminary trials in a small sample of a Western population suggested that this modality was safe. Most trials are performed in China thereby providing comprehensivedataforunderstandingthesafetyprofile.TheaimofthisstudywastoevaluateadverseeventsofUSgFU therapy. MethodsandFindings:Clinicaldataweresearchedin2Chinesedatabases.AdverseeventsofUSgFUweresummarizedand compared with those of magnetic resonance-guided HIFU (MRgFU; for uterine, bone or breast tumor) and transrectal ultrasound-guidedHIFU(forprostatecancerorbenignprostatehyperplasia).USgFUtreatmentwasperformedusing7types ofdevice.Sideeffectswereevaluatedin13262cases.Therewerefeweradverseeventsinbenignlesionsthaninmalignant lesions (11.81% vs. 21.65%, p,0.0001). Rates of adverse events greatly varied between the disease types (0–280%, p,0.0001)andbetweentheappliedHIFUdevicesinbothmalignant(10.58–44.38%,p,0.0001)andbenignlesions(1.67– 17.57%, p,0.0001). Chronological analysis did not demonstrate a decrease in the rate of adverse events. Based upon evaluableadverseevents,incidencesinUSgFUwereconsistentwiththoseinMRgFUortransrectalHIFU.Somesideeffects frequently occurred following transrectal HIFU were not reported in USgFU. Several events including intrahepatic metastasis, intraoperative high fever, and occlusions of the superior mesenteric artery should be of particular concern becausetheyhavenotbeenpreviouslynoted.Thetypesofadverseeventssu