Adipocyte Hypertrophy, Fatty Liver and Metabolic Risk Factors in South Asians The Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE) 英文参考文献.docVIP

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Adipocyte Hypertrophy, Fatty Liver and Metabolic Risk Factors in South Asians The Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE) 英文参考文献.doc

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Adipocyte Hypertrophy, Fatty Liver and Metabolic Risk Factors in South Asians The Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE) 英文参考文献

AdipocyteHypertrophy,FattyLiverandMetabolicRisk FactorsinSouthAsians:TheMolecularStudyofHealth andRiskinEthnicGroups(mol-SHARE) SoniaS.Anand1,2,4*,MarkA.Tarnopolsky2,3,ShiryaRashid2,KarleenM.Schulze1,DipikaDesai1 ,Andrew Mente4,SandyRao1,SalimYusuf1,2,4,HertzelC.Gerstein1,2,4,AryaM.Sharma2,5 1PopulationHealthResearchInstitute,HamiltonHealthSciencesandMcMasterUniversity,Hamilton,Ontario,Canada,2DepartmentofMedicine,McMasterUniversity, Hamilton,Ontario,Canada,3DepartmentofPediatrics,McMasterUniversity,Hamilton,Ontario,Canada,4DepartmentofClinicalEpidemiology/Biostatistics,McMaster University,Hamilton,Ontario,Canada,5UniversityofAlberta,Edmonton,Alberta,Canada Abstract Objective:WesoughttodetermineifdifferencesinthedistributionandcharacteristicsofadiposetissuebetweenSouth AsiansandwhiteCaucasiansaccountfordifferencesinriskfactorsforcardiovasculardisease. ResearchDesignandMethods:Werecruited108healthySouthAsians(36.8years)andwhiteCaucasians(34.2years)within threeBMIstrata.Bodycomposition,adipocytesize,abdominalfatarea,andhepaticadipositywereassessedandrelatedto fastingglucose,insulin,lipidsandadiponectin. Results:Afteradjustmentforage,sex,andBMI,SouthAsianscomparedtowhiteCaucasianshadhigherlnfastinginsulin (mean difference (md): 0.44; 95% CI: 0.20–0.69), lower HDL cholesterol (md: 20.13; 95% CI:20.26 to 20.01), and lower adiponectin(md:22.38;95%CI:23.59to21.17).SouthAsiansalsohadmorebodyfat(md:2.69;95%CI:0.70to4.69), lowerleanmusclemass(md:23.25;95%CI:25.35to21.14),increasedwaisttohipratio(md:0.03;95%CI:0.01–0.05),less superficialsubcutaneousabdominaladiposetissue(md:22.94;95%CI:25.56to20.32),moredeep/visceraltosuperficial adiposetissueratio(md0.34;95%CI:0.02to0.65),andmoreliverfat(md:7.43%;95%CI:2.30to12.55%).Adipocytearea was increased in South Asians compared to white Caucasians (md: 64.26; 95% CI: 24.3 to 104.1) units2. Adjustment for adipocyteareaattenuatedtheethnicdifferencesininsulin(md:0.22;95%CI:20.07to0.51),HDL(md:20.01;95%CI:20.16 to 0.13) and adiponectin (