An Image-Free Opto-Mechanical System for Creating Virtual Environments and Imaging Neuronal Activity in Freely Moving Caenorhabditis elegans 英文参考文献.docVIP
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An Image-Free Opto-Mechanical System for Creating Virtual Environments and Imaging Neuronal Activity in Freely Moving Caenorhabditis elegans 英文参考文献
AnImage-FreeOpto-MechanicalSystemforCreating
VirtualEnvironmentsandImagingNeuronalActivityin
FreelyMovingCaenorhabditiselegans
SergeFaumont1,GaryRondeau2,TodR.Thiele3,KristyJ.Lawton4,KathrynE.McCormick1 ,Matthew
Sottile5,OliverGriesbeck6,EllieS.Heckscher7,WilliamM.Roberts1,ChrisQ.Doe7,ShawnR.Lockery1*
1Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America, 2Applied Scientific Instrumentation, Eugene, Oregon, United States of
America, 3University of California San Francisco, San Francisco, California, United States of America, 4Department of Neurobiology and Behavior, Cornell University,
Ithaca, New York, United States of America, 5Galois Inc., Portland, Oregon, United States of America, 6Max-Planck-Institute of Neurobiology, Martinsried, Germany,
7HowardHughesMedicalInstitute,InstituteofNeuroscience,InstituteofMolecularBiology,UniversityofOregon,Eugene,Oregon,UnitedStatesofAmerica
Abstract
Non-invasiverecordinginuntetheredanimalsisarguablytheultimatestepintheanalysisofneuronalfunction,butsuch
recordingsremainelusive.Toaddressthisproblem,wedevisedasystemthattracksneuron-sizedfluorescenttargetsinreal
time. Thesystemcanbe usedtocreatevirtualenvironments byoptogenetic activationof sensory neurons,ortoimage
activityinidentifiedneuronsathighmagnification.ByrecordingactivityinneuronsoffreelymovingC.elegans,wetested
thelong-standinghypothesisthatforwardandreverselocomotionaregeneratedbydistinctneuronalcircuits.Surprisingly,
wefoundmotorneuronsthatareactiveduringbothtypesoflocomotion,suggestinganewmodeloflocomotioncontrolin
C.elegans.Theseresultsemphasizetheimportanceofrecordingneuronalactivityinfreelymovinganimalsandsignificantly
expandthepotentialofimagingtechniquesbyprovidingameantostabilizefluorescenttargets.
Citation:FaumontS,RondeauG,ThieleTR,LawtonKJ,McCormickKE,etal.(2011)AnImage-FreeOpto-MechanicalSystemforCreatingVirtualEnvironmentsand
ImagingNeuronalActivityinFreelyMovingCaenorhabditiselegans.PLoSONE6(9):e24666.doi:10.1371/
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