An Early Role for Wnt Signaling in Specifying Neural Patterns of Cdx and Hox Gene Expression and Motor Neuron Subtype Identity 英文参考文献.docVIP

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An Early Role for Wnt Signaling in Specifying Neural Patterns of Cdx and Hox Gene Expression and Motor Neuron Subtype Identity 英文参考文献.doc

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An Early Role for Wnt Signaling in Specifying Neural Patterns of Cdx and Hox Gene Expression and Motor Neuron Subtype Identity 英文参考文献

o PL SBIOLOGY AnEarlyRoleforWntSignalinginSpecifying NeuralPatternsofCdxandHoxGene ExpressionandMotorNeuronSubtypeIdentity Ulrika Nordstro¨m1,Esther Maier1,Thomas M.Jessell2,Thomas Edlund1* 1Umea? Centerfor Molecular Medicine,Umea? University, Umea?, Sweden,2Howard Hughes MedicalInstitute andCenterfor Neurobiology andBehavior,Deparment of BiochemistryandMolecularBiophysics,ColumbiaUniversity,NewYork,NewYork,UnitedStatesofAmerica The link between extrinsic signaling, progenitor cell specification and neuronal subtype identity is central to the developmentalorganizationofthevertebratecentralnervoussystem.Inthehindbrainandspinalcord,distinctionsin therostrocaudalidentityofprogenitorcellsareassociatedwiththegenerationofdifferentmotorneuronsubtypes. Twofundamentalclassesofmotorneurons,thosewithdorsal(dMN)andventral(vMN)exitpoints,aregeneratedover largely non-overlapping rostrocaudal domains of the caudal neural tube. Cdx and Hox genes are important determinants of the rostrocaudal identity of neural progenitor cells, but the link between early patterning signals, neuralCdxandHoxgeneexpression,andthegenerationofdMNandvMNsubtypes,isunclear.Usinganinvitroassay of neural differentiation, we provide evidence that an early Wnt-based program is required to interact with a later retinoic acid- and fibroblast growth factor–mediated mechanism to generate a pattern of Cdx and Hox profiles characteristicofhindbrainandspinalcordprogenitorcellsthatprefigurethegenerationofvMNsanddMNs. Citation:Nordstro¨mU,MaierE,JessellTM,EdlundT(2006)AnearlyroleforWntsignalinginspecifyingneuralpatternsofCdxandHoxgeneexpressionandmotorneuron subtypeidentity.PLoSBiol4(8):e252.DOI:10.1371/journal.pbio.0040252 distinct rhombomeres are delineated by the nested expres- sionof39Hoxgenes[3,15],whereasthespinalexpressionof59 Introduction During the early development of the vertebrate central nervous system, the position of generation of post-mitotic neuronsdependsonthepatterningofprogenitorcellsalong the