An Efficient Paradigm for Genetic Epidemiology Cohort Creation 英文参考文献.docVIP

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An Efficient Paradigm for Genetic Epidemiology Cohort Creation 英文参考文献.doc

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An Efficient Paradigm for Genetic Epidemiology Cohort Creation 英文参考文献

AnEfficientParadigmforGeneticEpidemiologyCohort Creation MartinLadouceur1,WilliamD.Leslie2,ZariDastani3,DavidGoltzman4,J.BrentRichards1,3,4,5* 1DepartmentofHumanGenetics,McGillUniversityandJewishGeneralHospital,Montreal,Canada,2DepartmentsofMedicineandRadiology,UniversityofManitoba, Winnipeg, Canada, 3Departments of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada, 4Department of Medicine, McGill UniversityandMcGillUniversityHealthCentre,Montreal,Canada,5TwinResearchandGeneticEpidemiology,King’sCollegeLondon,London,UnitedKingdom Abstract Developmentofnovelmethodologiestoefficientlycreatelargegeneticepidemiologycohortsisneeded.Herewedescribe arapid,preciseandcost-efficientmethodforcollectionofDNAfromcasespreviouslyexperiencinganosteoporoticfracture byidentifyingcasesusingandadministrativehealth-caredatabases.Overthecourseof14monthswecollectedDNAfrom 1,130 women experiencing an osteoporotic fracture, at a cost of $54 per sample. This cohort is among the larger DNA osteoporoticfracturecollectionsintheworld.Thenovelmethoddescribedaddressesamajorunmethealthcareresearch needandiswidelyapplicabletoanydiseasethatcanbeidentifiedaccuratelythroughadministrativedata. Citation:LadouceurM,LeslieWD,DastaniZ,GoltzmanD,RichardsJB(2010)AnEfficientParadigmforGeneticEpidemiologyCohortCreation.PLoSONE5(11): e14045.doi:10.1371/journal.pone.0014045 Editor:JoelJosephGagnier,UniversityofMichigan,Canada ReceivedJuly20,2010;AcceptedOctober14,2010;PublishedNovember18,2010 Copyright: ?2010 Ladouceur et al. This isan open-access article distributed under the terms of the CreativeCommonsAttribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This work was supported by grants from the Canadian Foundation for Innovation, the Canadian Institutes of Health Research (CIHR), Fonds de la rechercheensanteduQuebecandtheJewishGeneralHospital.Drs.Ladouceur,RichardsandDastaniar