An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Properties 英文参考文献.docVIP

AnORMOSIL-ContainingOrthodonticAcrylicResinwith ConcomitantImprovementsinAntimicrobialand FractureToughnessProperties Shi-qiangGong1.,JeevaniEpasinghe2.,FrederickA.Rueggeberg3,Li-naNiu4,DonaldMettenberg3, CynthiaK.Y.Yiu2,JohnD.Blizzard5,ChristineD.Wu6,JingMao1*,ConnieL.Drisko3,DavidH.Pashley3, FranklinR.Tay3* 1DepartmentofStomatology,TongjiHospital,HuazhongUniversityofScienceandTechnology,Wuhan,China,2PediatricDentistryandOrthodontics,TheUniversityof Hong Kong, Hong Kong SAR, China, 3College of Dental Medicine, Georgia Health Sciences University, Augusta, Georgia, United States of America, 4School of Stomatology,FourthMilitaryMedicalUniversity,Xi’an,China,5QuadsilInc.,Midland,Michigan,UnitedStatesofAmerica,6CollegeofDentistry,UniversityofIllinoisat Chicago,Illinois,UnitedStatesofAmerica Abstract Global increase in patients seeking orthodontic treatment creates a demand for the use of acrylic resins in removable appliancesandretainers.Orthodonticremovableappliancewearershaveahigherriskoforalinfectionsthatarecausedby the formation of bacterial and fungal biofilms on the appliance surface. Here, we present the synthetic route for an antibacterial and antifungal organically-modified silicate (ORMOSIL) that has multiple methacryloloxy functionalities attachedtoasiloxanebackbone(quaternaryammoniummethacryloxysilicate,orQAMS).Bydissolvingthewater-insoluble, rubbery ORMOSIL in methyl methacrylate, QAMS may be copolymerized with polymethyl methacrylate, and covalently incorporated in the pressure-processed acrylic resin. The latter demonstrated a predominantly contact-killing effect on StreptococcusmutansATCC36558andActinomycesnaselundiiATCC12104biofilms,whileinhibitingadhesionofCandida albicansATCC90028ontheacrylicsurface.Apartfromitsfavorableantimicrobialactivities,QAMS-containingacrylicresins exhibited decreased water wettability and improved toughness, without adversely affecting the flexural strength and modulus,watersorptionandsolubility,whencomparedwithQAMS-freeacry