Analysis of Inducible Nitric Oxide Synthase Gene Polymorphisms in Vitiligo in Han Chinese People 英文参考文献.docVIP

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Analysis of Inducible Nitric Oxide Synthase Gene Polymorphisms in Vitiligo in Han Chinese People 英文参考文献.doc

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Analysis of Inducible Nitric Oxide Synthase Gene Polymorphisms in Vitiligo in Han Chinese People 英文参考文献

AnalysisofInducibleNitricOxideSynthaseGene PolymorphismsinVitiligoinHanChinesePeople YingZhang,ChunyingLi*,KaiLi,LingLiu,ZheJian,TianwenGao* DepartmentofDermatology,XijingHospital,TheFourthMilitaryMedicalUniversity,Xi’an,China Abstract Background:Vitiligoisachronicdepigmentedskindisorderwithregionalmelanocytesdepletion.Thepathogenesiswas notcompletelyclarified.Recently,moreandmoreevidencesuggestedthatpolymorphismsofsomegenesareassociated with vitiligo risk. Here, we want to examine the association between the inducible nitric oxide synthase (iNOS) gene polymorphismsandtheriskofvitiligoinChinesepopulations. MethodsandPrincipalFindings:Inahospital-basedcase-controlstudyof749patientswithvitiligoand763age-andsex- matchedhealthycontrols,threepolymorphismsofiNOSgeneweregenotypedbyusingthePCR-restrictionfragmentlength polymorphism (PCR-RFLP) and mutagenically separated PCR (MS-PCR) methods, respectively. We found the iNOS-954 polymorphism was associated with a significantly higher risk of vitiligo (adjusted OR=1.36, 95% CI=1.02–1.81). Furthermore,thisassociationismorepronouncedinvulgarisvitiligo,activevitiligoandvitiligowithoutotherautoimmune diseasesinthestratificationstudy.AnalysisofhaplotypesshowedincreasedriskfortheC C C (OR=1.44,95% -1173 -954 Ex16+14 CI=1.01–1.74).Inaddition,theserumiNOSactivityissignificantlyassociatedwithiNOS-954combinedgenotype(GC+CC) andismuchhigherinvitiligopatientsthaninthecontrols(P,0.01).LogisticregressionanalysisofiNOSactivityshowed increasedriskbetweenhigheractivityandiNOS-954GRCvariantgenotypecarriers(Ptrend,0.001). ConclusionsandSignificance:INOSgenepolymorphismsmayplayanimportantroleinthegeneticsusceptibilitytothe developmentofvitiligo. Citation:ZhangY,LiC,LiK,LiuL,JianZ,etal.(2011)AnalysisofInducibleNitricOxideSynthaseGenePolymorphismsinVitiligoinHanChinesePeople.PLoS ONE6(12):e27077.doi:10.1371/journal.pone.0027077 Editor:PaulWrede,Charite′-Universita¨tsmedizin Berlin,Germany ReceivedApril14,2011;AcceptedOctober10,2011;PublishedDe