An RNA Transport System in Candida albicans Regulates Hyphal Morphology and Invasive Growth 英文参考文献.docVIP

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An RNA Transport System in Candida albicans Regulates Hyphal Morphology and Invasive Growth 英文参考文献.doc

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An RNA Transport System in Candida albicans Regulates Hyphal Morphology and Invasive Growth 英文参考文献

AnRNATransportSysteminCandidaalbicansRegulates HyphalMorphologyandInvasiveGrowth SarahL.Elson1,SuzanneM.Noble1,2,NormaV.Solis3,ScottG.Filler3,4,AlexanderD.Johnson1,5 * 1Department ofMicrobiologyandImmunology,UniversityofCalifornia SanFrancisco,SanFrancisco,California,United StatesofAmerica, 2Department ofMedicine, DivisionofInfectiousDiseases,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica,3LosAngelesBiomedicalResearchInstituteat Harbor-UCLAMedicalCenter,Torrance,California,UnitedStatesofAmerica,4DavidGeffenSchoolofMedicineatUCLA,LosAngeles,California,UnitedStatesofAmerica, 5DepartmentofBiochemistryandBiophysics,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica Abstract Localization of specific mRNAs is an important mechanism through which cells achieve polarity and direct asymmetric growth. Based on a framework established in Saccharomyces cerevisiae, we describe a She3-dependent RNA transport systeminCandidaalbicans,afungalpathogenofhumansthatgrowsasbothbudding(yeast)andfilamentous(hyphaland pseudohyphal)forms.Weidentifyasetof40mRNAsthatareselectivelytransportedtothebudsofyeast-formcellsandto thetipsofhyphae,andweshowthatmanyofthegenesencodedbythesemRNAscontributetohyphaldevelopment,as doesthetransportsystemitself.AlthoughthebasicsystemofmRNAtransportisconservedbetweenS.cerevisiaeandC. albicans,wefindthatthecargomRNAshavedivergedconsiderably,implyingthatspecificmRNAscaneasilymoveinand out of transport control over evolutionary timescales. The differences in mRNA cargos likely reflect the distinct selective pressuresactingonthetwospecies. Citation:ElsonSL,NobleSM,SolisNV,FillerSG,JohnsonAD(2009)AnRNATransportSysteminCandidaalbicansRegulatesHyphalMorphologyandInvasive Growth.PLoSGenet5(9):e1000664.doi:10.1371/journal.pgen.1000664 Editor:SueBiggins,FredHutchinsonCancerResearchCenter,UnitedStatesofAmerica ReceivedMay7,2009;AcceptedAugust26,2009;PublishedSeptember25,2009 Copyright: ? 2009 Elson et