An Insight into the Relationships between Hepcidin, Anemia, Infections and Inflammatory Cytokines in Pediatric Refugees A Cross-Sectional Study 英文参考文献.docVIP
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An Insight into the Relationships between Hepcidin, Anemia, Infections and Inflammatory Cytokines in Pediatric Refugees A Cross-Sectional Study 英文参考文献
AnInsightintotheRelationshipsbetweenHepcidin,
Anemia,InfectionsandInflammatoryCytokinesin
PediatricRefugees:ACross-SectionalStudy
SarahCherian1,2,3,DavidA.Forbes1,4,AngusG.Cook3,FrankM.Sanfilippo3,ErwinH.Kemna5,DorineW.
Swinkels5,DavidP.Burgner1,2*
1SchoolofPediatricsandChildHealth,UniversityofWesternAustralia,Perth,WesternAustralia,Australia,2PediatricInfectiousDiseasesandRefugeeHealth,Princess
Margaret Hospital for Children, Perth, Western Australia, Australia, 3School of Population Health, University of Western Australia, Perth, Western Australia, Australia,
4Pediatric Gastroenterology, Princess Margaret Hospital for Children, Perth, Western Australia, Australia, 5Department of Clinical Chemistry, Radboud University
NijmegenMedicalCentre,Nijmegen,TheNetherlands
Abstract
Background:Hepcidin,akeyregulatorofironhomeostasis,isincreasedinresponsetoinflammationandsomeinfections,
buttheinvivoroleofhepcidin,particularlyinchildrenwithirondeficiencyanemia(IDA)isunclear.Weinvestigatedthe
relationshipsbetweenhepcidin,cytokinesandironstatusinapediatricpopulationwithahighprevalenceofbothanemia
andco-morbidinfections.
Methodology/Principal Findings: African refugee children ,16years were consecutively recruited at the initial post-
resettlementhealthcheckwith181childrenmeetinginclusioncriteria.Dataonhematologicalparameters,cytokinelevels
andco-morbidinfections(Helicobacterpylori,helminthandmalaria)wereobtainedandurinaryhepcidinassaysperformed.
The primary outcome measure was urinary hepcidin levels in children with and without iron deficiency (ID) and/or ID
anaemia(IDA).Thesecondaryoutcomemeasuresincludedweretherelationshipbetweenco-morbidinfectionsand(i)ID
and IDA, (ii) urinary hepcidin levels and (iii) cytokine levels. IDA was present in 25/181 (13.8%). Children with IDA had
significantlylowerhepcidinlevels(IDAmedianhepcidin0.14nmol/mmolCr(interquartilerange0.05–0.061)versusnon-IDA
2.96nmol/mmol Cr, (IQR 0.95–6.72), p,0.001). Hemoglobin, log-ferritin, iron, mean cell volume
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