An Epididymis-Specific Secretory Protein HongrES1 Critically Regulates Sperm Capacitation and Male Fertility 英文参考文献.docVIP
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An Epididymis-Specific Secretory Protein HongrES1 Critically Regulates Sperm Capacitation and Male Fertility 英文参考文献
AnEpididymis-SpecificSecretoryProteinHongrES1
CriticallyRegulatesSpermCapacitationandMale
Fertility
YuchuanZhou1,MinZheng1,QixianShi2,LiZhang1,WeiZhen1,WenyingChen2,YonglianZhang1,3*
1Shanghai Key Laboratory for Molecular Andrology, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for
BiologicalSciences,ChineseAcademyofSciences,Shanghai,China,2UnitofReproductivePhysiology,ZhejiangAcademyofMedicalSciences,Hangzhou,Zhejiang,China,
3ShanghaiInstituteofPlannedParenthoodResearch,Shanghai,China
Abstract
Mammalian sperm capacitation is an essential prerequisite to fertilizion. Although progress had been made in
understanding the physiology and biochemistry of capacitation, little is known about the potential roles of epididymal
proteinsduringthisprocess.HerewereportthatHongrES1,anewmemberoftheSERPIN(serineproteinaseinhibitor)family
exclusivelyexpressedintheratcaudaepididymisandup-regulatedbyandrogen,issecretedintothelumenandcoversthe
sperm head. Co-culture of caudal sperms with HongrES1 antibody in vitro resulted in a significant increase in the
percentageofcapacitatedspermatozoa.Furthermore,thepercentageofcapacitatedspermatozoaclearlyincreasedinrats
whenHongrES1wasdown-regulatedbyRNAiinvivo.Remarkably,knockdownofHongrES1invivoledtoreducedfertility
accompanied with deformed appearance of fetuses and pups. These results identify HongrES1 as a novel and critical
moleculeintheregulationofspermcapacitationandmalefertility.
Citation:ZhouY,ZhengM,ShiQ,ZhangL,ZhenW,etal.(2008)AnEpididymis-SpecificSecretoryProteinHongrES1CriticallyRegulatesSpermCapacitationand
MaleFertility.PLoSONE3(12):e4106.doi:10.1371/journal.pone.0004106
Editor:DominikHartl,YaleUniversitySchoolofMedicine,UnitedStatesofAmerica
ReceivedSeptember29,2008;AcceptedNovember18,2008;PublishedDecember31,2008
Copyright: ? 2008 Zhou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
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